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Not yet recruitingNCT06210984Updated Jan 18, 2024

Caffeine and Training Intensity Quantification

An interventional study of Low caffeine dose and Moderate caffeine dose in Caffeine, sponsored by St. Mary's University, Twickenham. Not yet recruiting. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-01-18.

Sponsored by St. Mary's University, Twickenham · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Primary completion was expected by Dec 2025, 9 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The goal of this clinical trial is to learn about the effects of caffeine on exercise physiology and the subsequent quantification of athlete training zones in trained cyclists. The main questions that it aims to answer are:

  • What are the effects of low and moderate doses of caffeine on exercise physiology.
  • How do the effects of caffeine on exercise physiology affect the calculation of training zones.
  • Do the effects of caffeine on exercise physiology differ between men and women.

Participants will complete four trials on a cycle ergometer as follows:

  • Trial 1: participants will complete two incremental tests to determine the power outputs required to elicit 50-80% of maximal oxygen consumption for trials 2-4.
  • Trials 2-4: participants will consume (in a randomized order) either a low (2 mg/kg) dose of caffeine, a moderate (5 mg/kg) dose of caffeine, or a placebo (maltodextrin), 45 minutes prior to to completing an incremental cycling test from 50-80% of maximal oxygen uptake.

Measures of heart rate, oxygen uptake, blood lactate, and perceived exertion will be recorded throughout all trials.

Researchers will compare the effects of exercise intensity, caffeine dose, and sex to see if they affect exercise physiology and training zone quantification.

02

Conditions studied

  • Caffeine
03

In context

Lead sponsor

St. Mary's University, Twickenham is the lead sponsor of 16 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • To be considered for inclusion in the study, participants must be regular cyclists, between 18 and 45 years of age, capable of completing a 20 km cycling time trial at a minimum speed of 30 km/h for men and 28 km/h for women (arbitrary inclusion criteria to ensure a sufficient standard of athlete). Female participants must have a regular menstrual cycle and not be taking oral contraceptives.

Exclusion criteria

Exclusion Criteria:

-

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
36 participants (estimated)

Study arms

  • Experimental
    Low caffeine dose

    2 mg/kg dose of caffeine (in pill form)

    Drug: Low caffeine dose

  • Experimental
    Moderate caffeine dose

    5 mg/kg dose of caffeine (in pill form)

    Drug: Moderate caffeine dose

  • Placebo comparator
    Placebo

    5 mg/kg dose of placebo (Maltodextrin in pill form)

    Drug: Placebo

Interventions

  • DrugLow caffeine dose

    2 mg/kg dose of caffeine in pill form

  • DrugModerate caffeine dose

    5 mg/kg dose of caffeine in pill form

  • DrugPlacebo

    5 mg/kg dose of maltodextrin in pill form

06

What researchers measure

Primary outcomes

  1. Blood lactate concentration

    Change from baseline in blood lactate concentration measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

    Time frame: From baseline to completion, up to 31 days

  2. Heart rate

    Change from baseline in heart rate measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

    Time frame: From baseline to completion, up to 31 days

  3. Oxygen uptake

    Change from baseline in oxygen uptake measured at rest and at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

    Time frame: From baseline to completion, up to 31 days

  4. Perceived exertion

    Change from baseline in rating of perceived exertion measured (using the 6-20 Borg scale) at seven different exercise intensities (50, 55, 60, 65, 70, 75, and 80% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer

    Time frame: From baseline to completion, up to 31 days

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 18, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06210984
Lead sponsor
St. Mary's University, Twickenham
Responsible party
Sponsor
First posted
Jan 18, 2024
Start date
Jan 31, 2024 (estimated)
Primary completion
Dec 31, 2025 (estimated)
Completion
Dec 31, 2025 (estimated)
Last update
Jan 18, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.

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