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CompletedNCT06196138Updated Mar 27, 2026

The Effect of Chewing Gum and Hot Compresses on Gynecologic Oncologic Surgery

An interventional study of Gum and Hot Compress in Gynecologic Nursing and Pain, sponsored by Istanbul Medeniyet University. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-27.

Sponsored by Istanbul Medeniyet University · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
84
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

The passage discusses the recovery of gastrointestinal (GI) function after abdominal surgery and the potential impact on patient comfort. After surgery, small bowel activity typically returns to normal within a few hours, gastric activity within 24-48 hours, and colonic activity within 48-72 hours. However, the delayed mobility of the GI system postoperatively can lead to issues such as abdominal bloating, nausea, vomiting, and pain. These symptoms can negatively affect patient comfort, leading to increased post-operative pain, decreased mobility, reduced satisfaction, and a longer hospital stay. Therefore, interventions that expedite the normalization of bowel activity are crucial. Chewing is suggested to stimulate intestinal motility by activating the cephalovagal pathway, which influences neurogenic and hormonal factors regulating GI functions. Postoperative heat application aims to prevent hypothermia, enhance bodily functions, and potentially promote bowel motility by stimulating somatic nerves. The study explores the effects of gum chewing and hot application protocols on postoperative pain, bowel function, and patient comfort after gynecologic oncologic surgery. It aims to contribute valuable insights to the existing literature on postoperative outcomes.

Read the detailed description

After abdominal surgery, small bowel activity returns to normal within a few hours, gastric activity within 24-48 hours, and colonic activity within 48-72 hours. Due to the delayed mobility of the gastrointestinal (GI) system in the postoperative period, gas and secretions accumulated in the stomach and intestines cause abdominal bloating, nausea, vomiting, and pain, negatively impacting patient comfort. This can lead to increased post-operative pain, decreased post-operative mobility, decreased patient satisfaction and prolonged hospital stay. Therefore, procedures that shorten the time to normalization of bowel activity in the postoperative period are very important. Chewing stimulates intestinal motility in humans. The chewing mechanism is thought to work by stimulating the cephalovagal pathway. Stimulation of the cephalovagal pathway stimulates various neurogenic and hormonal factors that modulate the functions of the gastrointestinal tract. Problems related to decreased intestinal motility after minimally invasive surgery can cause postoperative side effects due to delayed recovery of GI function. The basic rationale of postoperative heat application is to prevent the development of hypothermia during and after surgery by regionally warming the patient's body, eliminating the slowing effect of hypothermia, and helping to activate bodily functions early. It has been suggested that heat application may reflexively promote bowel motility by stimulating somatic nerves via the supraspinal or spinal cord, and it has been demonstrated that stimulation of warm receptors in the skin with heat may reflexly inhibit sympathetic nerves and promote parasympathetic nerve activity in the bowel as a supraspinal and spinal reflex. There are few studies in the literature examining the effect of chewing gum and heat application on postoperative outcomes after gynecologic oncologic surgery. No study was found that compared the two applications. This study was designed to compare the effects of gum chewing and hot application protocols on postoperative pain, bowel function, and patient comfort after gynecologic oncologic surgery. It is believed that this study will make an important contribution to the literature.

02

Conditions studied

  • Gynecologic Nursing
  • Pain

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03

In context

Pain

2,219 studies on the registry are indexed under Pain; 917 are open to participants now.

This study's enrollment of 84 is above the median of 70 across 1,904 interventional studies indexed under Pain.

Browse Pain studies →

Lead sponsor

Istanbul Medeniyet University is the lead sponsor of 188 studies on the registry; 18 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • 18 years of age or older
  • To undergo elective minimally invasive gynecologic surgery
  • No cognitive, affective and mental problems that would prevent gum chewing and hot application
  • Does not have any chronic disease
  • No previous abdominal surgery
  • Turkish speaking and
  • Women who volunteer to participate in the study will be included.

Exclusion criteria

Exclusion Criteria:

  • Who wants to leave the work for any reason
  • History of ileostomy and colostomy
  • He was taken to intensive care after the surgery and
  • Women with postoperative complications (bleeding, infection, etc.) will be excluded from the study.
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
84 participants (actual)

Study arms

  • Experimental
    Gum

    Patients who will chew gum after surgery will constitute this group

    Other: Gum

  • Experimental
    Hot Compress

    Patients who will undergo hot compress after surgery will constitute this group

    Other: Hot Compress

  • No intervention
    Control

    Patients who will undergo routine protocol will constitute this group

Interventions

  • OtherGum

    In the postoperative period, starting from the 4th hour, chewing gum is done 3 times a day, morning, noon and evening, for 30 minutes each, until the patient passes the first flatus.

  • OtherHot Compress

    Starting from the 1st postoperative day, patients will receive hot application (to the lumbar region) for 10 minutes in the morning and evening. The hot application is applied by wrapping 2 towels in a water bag containing 55 ± 2 °C hot water. The water bag is applied to the lumbar region for 10 minutes with the patient in the supine position. The application is continued until the patient passes the first flatus.

06

What researchers measure

Primary outcomes

  1. Visual Analog Scale

    This scale, which can be used horizontally or vertically, is shaped like a 10 cm line. The scale begins with "No pain" and ends with "My pain is very severe. The person is asked to select a number between 0 and 10 that corresponds to the pain they feel on this scale.

    Time frame: 8 months

  2. General Comfort Scale

    The highest total score that can be obtained from the scale is 192 and the lowest total score is 48. Obtained The total score depends on the number of scale items.

    Time frame: 8 months

07

Study locations

1 site
  • Dr. Abdurrahman Yalcin Training and Research Hospital
    Ankara, Turkey (Türkiye)
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References and documents

Publications

  • Akladios C, Darai E, Golfier F, Lecuru F, Collinet P, Uzan C, Lavoue V, Guyon F, Ferron G, Querleu D. [National certification for gynecological cancer surgery]. Bull Cancer. 2021 Sep;108(9):806-812. doi: 10.1016/j.bulcan.2021.03.019. Epub 2021 Jun 30. French. PubMed 34217437 ↗
  • Schneider S, Armbrust R, Spies C, du Bois A, Sehouli J. Prehabilitation programs and ERAS protocols in gynecological oncology: a comprehensive review. Arch Gynecol Obstet. 2020 Feb;301(2):315-326. doi: 10.1007/s00404-019-05321-7. Epub 2019 Oct 15. PubMed 31616986 ↗
  • Nanthiphatthanachai A, Insin P. Effect of Chewing Gum on Gastrointestinal Function Recovery After Surgery of Gynecological Cancer Patients at Rajavithi Hospital: A Randomized Controlled Trial. Asian Pac J Cancer Prev. 2020 Mar 1;21(3):761-770. doi: 10.31557/APJCP.2020.21.3.761. PubMed 32212805 ↗
  • Phutsisen J, Kietpeerakool C, Jampathong N, Chumworathayi B, Temtanakitpaisan A, Aue-Aungkul A, Boontasaeng P. Effects of Cassia alata Linn on bowel function recovery following surgery for gynecological cancer: A randomized controlled trial. Complement Ther Med. 2019 Dec;47:102222. doi: 10.1016/j.ctim.2019.102222. Epub 2019 Oct 21. PubMed 31779993 ↗
  • Yin YN, Xie H, Ren JH, Jiang NJ, Dai L. The impact of gum-chewing on postoperative ileus following gynecological cancer surgery: A systematic review and meta-analysis of randomized controlled trials. Front Oncol. 2023 Jan 17;12:1059924. doi: 10.3389/fonc.2022.1059924. eCollection 2022. PubMed 36733360 ↗

Individual participant data

Plan to share: Undecided — A decision will be made by the researchers at the end of the research.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06196138
Lead sponsor
Istanbul Medeniyet University
Collaborators
Istanbul University, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Responsible party
Eda Polat (Research Asisstant, Istanbul Medeniyet University) — Principal investigator
First posted
Jan 9, 2024
Start date
Jan 1, 2024
Primary completion
Nov 1, 2024
Completion
Dec 1, 2024
Last update
Mar 27, 2026

Study contacts

Merve Beke, MSc
principal investigator · Dr. Abdurrahman Yalcin Training and Research Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.

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