A Prospective, Open, Self-controlled Study of the Effects of Chiglitazar Sodium on Glucose and Lipid Metabolism in Patients With Type 2 Diabetes Mellitus (T2DM)

1. Patients with type 2 diabetes (T2DM) WHO meet the diagnostic criteria for diabetes issued by the World Health Organization (WHO) in 1999;
2. Male or female patients aged ≥18, ≤70 years;
3. BMI≥18.5 Kg/m2, \< 35 Kg/m2;
4. Hemoglobin a1C (HbA1C) ≥7.5%; ≤10.5%;
5. Triglyceride ≤500 mg /dL (5.65 mmol/L) (if the researchers judge that the transient increase caused by diet, etc., can be repeated detection)
6. Total cholesterol (TC) ≤250mg/dl (6.45mmol/L)
7. T2DM patients who are taking one or two kinds of oral hypoglycemic drugs with fixed dose ≥2 months and uncontrolled blood glucose.
8. Voluntarily sign informed consent and agree to enter the trial group.

Exclusion Criteria:

1. Type 1 diabetes or other specific type of diabetes
2. Fasting blood glucose (FPG) > 13.3 mmol/L (240 mg/dL);
3. Triglyceride (TG) > 500 mg /dL (5.65 mmol/L);
4. Total cholesterol (TC) > 250mg/dl (> 6.45mmol/L);
5. Refractory hypertension [that is, on the basis of improving the lifestyle, the blood pressure is still not up to standard after 1 month of applying a reasonably tolerable amount of 3 or more antihypertensive drugs (including diuretics), or the blood pressure can be effectively controlled by taking 4 or more antihypertensive drugs;
6. Taking fibrates, statins, thiazolidinediones, insulin drugs;
7. A clear diagnosis of severe osteoporosis or any other known bone disease;
8. A history of diabetic ketoacidosis, diabetic hyperglycemia hyperosmolar syndrome, lactic acidosis and other acute complications of diabetes;
9. Severe microvascular complications (proliferative retinopathy; Urinary albumin/creatinine ratio > 300 mg/g; Marked peripheral neuropathy, etc.);
10. The New York Heart Association (NYHA) defines congestive heart failure as grade III or IV;
11. Significant liver and kidney dysfunction and systemic disease (significant liver dysfunction is defined as AST> 2.5 times the upper limit of normal and/or ALT> 2.5 times the upper limit of normal and/or total bilirubin > 1.5 times the upper limit of normal value; Renal dysfunction was defined as moderate to severe renal insufficiency (eGFR\<60 ml/ (min*1.73m2));
12. Pregnant or lactating women, women of childbearing age who are unable or unwilling to take adequate contraception;
13. Participating in a clinical trial of another drug or medical device in or within 3 months prior to screening;
14. The investigator considers it inappropriate to participate in this clinical trial.