An interventional study of Lugol's iodine solution 5% in Toxic; Thyroid, sponsored by Aristotle University Of Thessaloniki. Active, not recruiting at 1 site in Greece. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-20.
Sponsored by Aristotle University Of Thessaloniki · Not applicable, Interventional, and Treatment
Lugol's solution and other preparations containing iodide have been used as an adjuvant treatment in patients with toxic disease planned for thyroidectomy. However, no conclusive evidence supporting the benefits of preoperative treatment with LS for patients with toxic goiters. This trial aims to provide new insights into future recommendations.
967 studies on the registry are indexed under Thyroid Diseases; 197 are open to participants now.
This study's planned enrollment of 50 is below the median of 60 across 544 interventional studies indexed under Thyroid Diseases.
Browse Thyroid Diseases studies →Aristotle University Of Thessaloniki is the lead sponsor of 274 studies on the registry; 56 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
euthyroid patients undergoing total thyroidectomy for toxic thyroid disease, no preoperative preparation with 5% lugols solution
euthyroid patients undergoing total thyroidectomy for toxic thyroid disease, preoperative preparation with 5% lugols solution for 10 days
Dietary Supplement: Lugol's iodine solution 5%
4 drops of LS every 8 hours for 10 days preoperatively will be given
Thyroidectomy complications rate
postoperative bleeding, hypoparathyroidism and recurrent laryngeal nerve palsy will be recorded
Time frame: 24 hours postoperatively
Thyroid volume
via ultrasound
Time frame: Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup.
Superior thyroid artery blood flow
via ultrasound
Time frame: Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup.
Fibrinogen
Sera, stored at -80 C until they were used
Time frame: Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup.
Vascular endothelial growth factor
Sera, stored at -80 C until they were used
Time frame: Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup.
Interleukin-16 serum levels
Sera, stored at -80 C until they were used
Time frame: Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup.
Thromboelastography
Thromboelastography assay
Time frame: Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup.
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.
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Aristotle University Of Thessaloniki