An observational study in Bronchiolitis, sponsored by Assistance Publique - Hôpitaux de Paris. Recruiting at 3 sites in France. Open to participants aged 1 Day to 12 Months. Per ClinicalTrials.gov, last updated 2025-02-26.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.
365 studies on the registry are indexed under Bronchiolitis; 45 are open to participants now.
This study's planned enrollment of 120 is below the median of 192 across 95 observational studies indexed under Bronchiolitis.
Browse Bronchiolitis studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,576 studies on the registry; 1,028 are open to participants now.
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Bronchiolitis in patient under 12 months old
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Exclusion Criteria:
venous blood samples. Buccal, nasopharyngeal and rectal swabs
Other: Sampling
Capillary blood samples. Buccal, nasopharyngeal and rectal swabs
Other: Sampling
Capillary blood samples. Buccal, nasopharyngeal and rectal swabs
Single-time sampling of respiratory virus-infected children
Dysbiosis
comparison of the quantitative and qualitative composition of bacteria (alpha diversity, beta diversity, Shannon and Simpson index) in the digestive and nasopharyngeal microbiota
Time frame: Inclusion
Measurement of innate and adaptive responses by quantification of cytokines and chemokines in plasma
Inflammatory/regulatory cytokines (IL1-\>17, IL-10, TGF-b, EGF, FGF-2, IFN-alpha, IFN-gamma, IFN-beta, MCRP-1 MCP-3, TNF-alpha...), cytokines of adaptative response (Th1, Th17, Th2 and/or Treg), markers of inflammatory response (interferon, TNFa, …), quantified by Luminex
Time frame: inclusion
Identifying the mRNA profile in blood samples and nasal swabs
mRNA will be identified by using RNA-Seq (Illumina)
Time frame: inclusion
Sequencing viral strains for mutation
Typing of respiratory syncytial virus-A (RSV-A) and B (RSV-B) and sequencing of strains (Amplicons)
Time frame: Inclusion
Comparison of respiratory syncytial virus (RSV) antibodies levels on newborn screening specimen and on capillary swab during infection
Levels of RSV antibodies will be measured and compared between newborn screening specimen and capillary swab during infection
Time frame: Birth, Inclusion
Study the load of Streptococcus pneumoniae (Sp) in RSV infections.
Compare the serotypic profiles of pneumococcus (Sp) present during RSV infections
Time frame: Inclusion
Plan to share: No
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