A Phase 2 interventional study of Double trigger and HCG trigger in Infertility, sponsored by Bedaya Hospital. Not yet recruiting at 1 site in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2023-11-29.
Sponsored by Bedaya Hospital · Phase 2, Interventional, and Treatment
The aim of this study is to compare the efficacy double trigger [ co-administration of GnRH agonist with HCG 40 and 34 h prior to ovum pick-up, respectively] with HCG trigger in inducing oocyte maturation.
Several studies revealed that the double trigger regimen was effective in the treatment of patients with a history of immature oocytes retrieved or with suboptimal oocytes yield.
The investigators designed this randomized controlled trial to compare the efficacy double trigger with HCG trigger in inducing oocyte maturation.in normoreponders undergoing IVF-ET
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's planned enrollment of 150 is above the median of 120 across 1,698 interventional studies indexed under Infertility.
Browse Infertility studies →Bedaya Hospital is the lead sponsor of 5 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) and hCG ( 10000 IU) are administered 40 and 34 h before oocyte retrieval
Drug: Double trigger
HCG ( 100000 IU/ I.M ) is administered 36 h before oocyte retrieval
Drug: HCG trigger
GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) and hCG ( 10000 IU) are administered 40 and 34 h before ovum pick-up
Also known as: Augmented trigger
hCG ( 10000 IU) is administered 36 h before ovum pick-up
Also known as: Conventional trigger
Metaphase-II oocytes rate
Number of MII oocyte/ number of cumulus oocyte complex
Time frame: Ten to fifteen days after starting ovarian stimulation
Clinical pregnancy rate
Presence of intrauterine gestational sac detected by transvaginal ultrasound
Time frame: 5 weeks after embryo transfer
Ongoing Pregnancy Rate
Pregnancies continued beyond 20 weeks gestation
Time frame: 18 weeks after embryo transfer
This study is not yet recruiting, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
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Bedaya Hospital