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CompletedNCT06129227Updated Sep 17, 2026

Brain Activity Changes After Structured Cognitive-motor Exercise for People With Stroke

An interventional study of Dual-task training and Single-task training in Stroke, sponsored by The Hong Kong Polytechnic University. Completed at 1 site in Hong Kong. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-09-17.

Sponsored by The Hong Kong Polytechnic University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
108
Allocation
Randomized
Ages
50 Years and older
Sex
All
01

Study summary

To assess the effects of a dual-task exercise program on cognitive-motor interference during dual-task walking and the associated changes in brain activity.

Read the detailed description

Stroke is one of the leading causes of chronic disability in Hong Kong and other parts of the world. Mobility dysfunctions are among the most common impairments observed after stroke. Restoration of mobility is also a top priority in rehabilitation goal-setting by stroke patients. In daily life, functional ambulation in the community requires the ability to maintain walking balance while simultaneously engaging in other attention-demanding tasks (i.e., dual-tasking), such as walking when holding a conversation, or crossing the street while attending to traffic signals. There is increasing evidence that performing a cognitive task in conjunction with a mobility task would cause more severe degradation of one or both tasks among stroke patients when compared with age-matched able-bodied individuals. This phenomenon, termed "cognitive-motor interference", should warrant detailed study, since it has an important impact on community-living among people with stroke.

02

Conditions studied

  • Stroke

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Keywords

  • Dual-task training
  • Cognitive-motor interference
03

In context

Stroke

7,283 studies on the registry are indexed under Stroke; 2,013 are open to participants now.

This study's enrollment of 108 is above the median of 50 across 5,366 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

The Hong Kong Polytechnic University is the lead sponsor of 659 studies on the registry; 250 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosis of stroke confirmed by brain scan reports
  • Community-living
  • Stroke onset ≥ 6 months
  • Aged 50 years or older
  • Modified Rankin scale 1-3
  • Capable of following verbal instructions
  • Montreal Cognitive Assessment score ≥ 22
  • Ability to walk for 1 min independently with or without a walking aid
  • Not receiving formal rehabilitation elsewhere

Exclusion criteria

Exclusion Criteria:

  • Other neurological disorders
  • Pain or other comorbidities that seriously affect the ability to walk
  • Contraindications to exercise (e.g., angina).
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
108 participants (actual)

Study arms

  • Experimental
    Dual-task training

    Mobility tasks performed in conjunction with cognitive tasks

    Behavioral: Dual-task training

  • Active comparator
    Single-task training

    Separate cognitive and mobility exercises

    Behavioral: Single-task training

  • Active comparator
    Control group

    Upper limb strengthening and flexibility exercises

    Behavioral: Control group

Interventions

  • BehavioralDual-task training

    This group will receive 30 min of dual-task exercise training and 30 min of stretching exercises in each session. The dual-task component involves walking activities performed in conjunction with cognitive activities. For the stretching exercise component, no cognitive load will be added.

  • BehavioralSingle-task training

    This group will undergo 30 min of single-task mobility training and another 30 min of single-task cognitive activities. The cognitive and mobility exercises will be the same as those in the dual-task group, but they will be performed separately. No extra cognitive load will be imposed during the mobility exercises. No additional motor demand will be imposed during the cognitive exercises, as the participants will be sitting.

  • BehavioralControl group

    This group will undergo 30 min of stretching exercises (same as the dual-task group) and another 30 min of upper limb strengthening exercises performed primarily in the sitting or lying position. No cognitive load will be added.

06

What researchers measure

Primary outcomes

  1. Dual-task gait speed

    Gait speed under dual-task condition will be recorded

    Time frame: Through study completion, an average of 1 year

  2. Dual-task cognitive performance

    Number of correct responses will be measured during dual-task walking

    Time frame: Through study completion, an average of 1 year

Secondary outcomes

  1. Dual-task gait performance 1

    Gait cadence will be measured during dual-task walking

    Time frame: Through study completion, an average of 1 year

  2. Dual-task gait performance 2

    Stride length will be measured during dual-task walking

    Time frame: Through study completion, an average of 1 year

  3. Dual-task gait performance 3

    Trunk stability will be measured during dual-task walking

    Time frame: Through study completion, an average of 1 year

  4. Oxyhemoglobin concentration changes of the brain

    Oxyhemoglobin concentration changes will be measured using functional near infra-red spectroscopy during dual-task walking

    Time frame: Through study completion, an average of 1 year

Other outcomes

  1. Balance 1

    Mini Balance Evaluation Systems Test will be used to assess postural control, with total points from 0-28. Higher points indicate better performance.

    Time frame: Through study completion, an average of 1 year

  2. Balance 2

    Activities-specific Balance Confidence Scale will be used to assess confidence of functional balance performance, with total points from 0-100. Higher points indicate better performance.

    Time frame: Through study completion, an average of 1 year

  3. Single-task walking speed

    10-meter walking test will be used to assess single-task walking speed in meters per second

    Time frame: Through study completion, an average of 1 year

  4. Cognitive performance 1

    Digit Span Test will be used to assess working memory

    Time frame: Through study completion, an average of 1 year

  5. Cognitive performance 2

    Montreal Cognitive Assessment will be used to assess global cognition, with total points from 0-30. Higher points indicate better performance.

    Time frame: Through study completion, an average of 1 year

  6. Fall incidence

    Monthly telephone interviews for recording fall incidence

    Time frame: Through study completion, an average of 1 year

07

Study locations

1 site
  • The Hong Kong Polytechnic University
    Hong Kong, Hong Kong 000000, Hong Kong
08

References and documents

Individual participant data

Plan to share: Yes — The study data can be provided via contacting the Principal Investigator

Supporting information: Study protocol, Sap, Icf, Csr

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 17, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06129227
Lead sponsor
The Hong Kong Polytechnic University
Collaborators
Research Grants Council, Hong Kong
Responsible party
Marco Yiu-Chung Pang (Chair professor, The Hong Kong Polytechnic University) — Principal investigator
First posted
Nov 13, 2023
Start date
Nov 22, 2023
Primary completion
Jun 30, 2025
Completion
Jun 30, 2026
Last update
Sep 17, 2026

Study contacts

Marco Yiu Chung PANG, PhD
principal investigator · The Hong Kong Polytechnic University
Xun LI, MSc
study director · The Hong Kong Polytechnic University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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