An interventional study of The lying flat (0°-10°) head position for 72 hours and The The head elevation (30°-40°) position for 72 hours in Stroke, Acute and Endovascular Therapy, sponsored by Zhengzhou Yuan. Completed at 67 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-11-28.
Sponsored by Zhengzhou Yuan · Not applicable, Interventional, and Other
The aim of this trial is to investigate whether head elevation position after endovascular treatment can improve the 90-day functional outcome of acute large vessel occlusion in the anterior circulation.
The optimal head position for patients with acute ischemic stroke (AIS) remains uncertain. The HeadPoS study revealed that there is no significant difference in disability outcomes between patients who are placed in a lying-flat position for 24 hours and those who are placed in a sitting-up position with the head elevated to at least 30 degrees for 24 hours. However, this study included both patients with ischemic and hemorrhagic strokes, and most of the patients had mild strokes (median National Institutes of Health Stroke Scale score of 4). It is unclear how to arrange the patient's head position after endovascular treatment.
The hypothesis of this trial: Compared with the lying flat head positioni, the head elevation position after endovascular treatment can significantly improve the 90-day functional outcome of acute large vessel occlusion in the anterior circulation.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 1,368 is above the median of 50 across 5,369 interventional studies indexed under Stroke.
Browse Stroke studies →Zhengzhou Yuan is the lead sponsor of 3 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients in lying flat intervention to be nursed lying flat (0°-10°) after endovascular therapy is made and to remain in this position for 72 hours.
Other: The lying flat (0°-10°) head position for 72 hours
Patients in the sitting up intervention should be nursed with their head elevated (30°-40°) by raising the head of the bed (or using extra pillows or wedges) after undergoing endovascular therapy, and to remain in this position for 72 hours.
Other: The The head elevation (30°-40°) position for 72 hours
The lying flat (0°-10°) head position for 72 hours after endovascular therapy.
The head elevoatin (30°-40°) position for 72 hours after endovascular therapy.
Modified Rankin scale score (mRS)
disability level. The presence of impairments determines the transitions from mRS score 0 to mRS score 1 (symptoms) and mRS score 5 to mRS score 6 (death).
Time frame: 90 days
Proportion of patients non-disabled (mRS score 0 to 1) or return to pre-morbid mRS score at 90 days (for patients with mRS > 1)
excellent outcome
Time frame: 90 days
Proportion of patients functionally independent (mRS score 0 to 2) at 90 days
functional independence
Time frame: Within 90 days90 days
Proportion of patients ambulatory or bodily needs-capable or better (mRS score 0 to 3)
ambulatory or bodily needs-capable or better
Time frame: 90 days
Health-related quality of life, assessed with the EuroQol-visual analogue scales (EQ-VAS)
Health-related quality of life
Time frame: 90 days
Mortality within 90 days
evaluate death rate of the two treatment groups
Time frame: 90 days
severe adverse events
evaluate complications and any adverse events
Time frame: within 90 days
Symptomatic intracerebral hemorrhage incidence (Heidelberg Criteria)
evaluate intracranial hemorrhage
Time frame: within 72 hours after randomized
Any type of intracerebral hemorrhage (Heidelberg Criteria)
evaluate intracranial hemorrhage
Time frame: within 72 hours after randomized
Brain edema
evaluate brain edema
Time frame: within 72 hours after randomized
Malignant Brain Edema
evaluate brain edema
Time frame: within 72 hours after randomized
Incidence of pulmonary infections
evaluate pulmonary infections
Time frame: within 72 hours after randomized
Improvement in National Institute of Health stroke scale (NIHSS) score between baseline and 5~7d
neurological changes.
Time frame: at 5~7 days after randomization
Plan to share: No
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This study is completed, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.
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