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CompletedNCT06107140TOBITUpdated Nov 1, 2023

Duration of Dual Antiretroviral Therapy in Virologically Suppressed People Living With HIV and Factors Associated With Switching to Tritherapy : a Real-life Cohort

An observational study in HIV Infections, sponsored by Tourcoing Hospital. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-11-01.

Sponsored by Tourcoing Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
580
Ages
18 Years and older
Sex
All
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Study summary

HIV infection requires lifelong continuous antiretroviral (ARV) treatment. The efficacy of current ARV treatments makes it possible to propose strategies for reducing the cumulative exposure to ARVs, side effects and costs. And so improve the quality of life of people living with HIV (PLHIV). However, in the real world, less regular adherence to treatment, more heavily pre-treated patients and resistance to treatment make these dual therapies prescribed beyond the strict framework of clinical trials. This can lead to undesirable side effects. From the perspective of personalized medicine, it seems to be important to determine which patients are receiving dual ARV therapy, and which patients remain on it for a long time. Identifying prognostic factors would enable us to adapt therapeutic management.

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Conditions studied

  • HIV Infections

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Keywords

  • epidemiology
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In context

HIV Infections

4,258 studies on the registry are indexed under HIV Infections; 240 are open to participants now.

This study's enrollment of 580 is above the median of 200 across 713 observational studies indexed under HIV Infections.

Browse HIV Infections studies →

Lead sponsor

Tourcoing Hospital is the lead sponsor of 21 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients followed up in a referral center for the management of PLHIV who started dual antiretroviral therapy in the period from 2011 to 2023 and whose viral load was \< 50 copies/ml before initiation of dual therapy.

Inclusion criteria

  • hiv patient
  • viral load \< 50copies/ml
  • patient treated with dual therapy
  • patients with hospital follow-up between 2011 and 2023

Exclusion criteria

Exclusion Criteria:

  • adults under legal protection
  • underage
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
580 participants (actual)
Patient registry
No

Interventions

  • Otherdual therapy

    The evaluation will focus on the retention of patients living with hiv on dual antiretroviral therapy.

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What researchers measure

Primary outcomes

  1. therapeutic switch

    Proportion of patients switching from dual to triple therapy

    Time frame: 5 years

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Study locations

1 site
  • Centre Hospitalier DRON
    Tourcoing, 59208, France
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 1, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06107140
Lead sponsor
Tourcoing Hospital
Responsible party
Sponsor
First posted
Oct 30, 2023
Start date
Jan 1, 2011
Primary completion
May 1, 2023
Completion
May 1, 2023
Last update
Nov 1, 2023

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.

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