An interventional study of High flow nasal canula in Healthy Volunteers, Diaphragm and Respiratory Rate, sponsored by Argentinian Intensive Care Society. Completed at 1 site in Argentina. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-10-17.
Sponsored by Argentinian Intensive Care Society · Not applicable, Interventional, and Basic science
The use of high-flow nasal cannula (HFNC) has increased. Diaphragmatic ultrasonography is a tool that, as a noninvasive complement to esophageal pressure (Pes) measurement, allows the evaluation of diaphragm function and reflects, through the diaphragm thickening fraction (DTf), the magnitude of diaphragmatic fiber recruitment. The objective of this study was to evaluate the impact of HFNC therapy on the DTf in healthy subjects. Second, this study aimed to assess the behavior of the respiratory rate (RR) and the work of breathing in these subjects.
Argentinian Intensive Care Society is the lead sponsor of 12 studies on the registry; 3 are open to participants now.
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Measurement of diaphragm thickening fraction, respiratory rate and esophageal pressure swing with calculation of diaphragmatic pressure-time product without the use of HFNC and with the use of HFNC at 20 and 40 Liters per minute
Also known as: diaphragm thickening fraction, esophageal pressure swing, Respiratory rate
Diaphragm thickening fraction.
ultrasound measurements were performed by an expert operator (the same in all cases). The ultrasound measurement was performed using a high-resolution linear transducer in real-time in B-mode. The diaphragm thickness was measured at the end of expiration and the end of inspiration of the same ventilatory cycle and the average value of 3 ventilatory cycles was recorded. A 2-minute washout period was allowed between each test condition to avoid the summation of effects. The DTf and PTPes/min were calculated for each subject in each available condition (baseline - without flow- , wtih 20 and 40 liters per minute): DTf = End Inspiratory Diaphragm thickening - End Expiratory Diaphragm thickening / End Expiratory Diaphragm thickening x 100
Time frame: Immediately after 5 min of each condition (baseline, 20 and 40 liters per minute) the diaphragmatic thickness was measured at the end of inspiration y de la expiration during 3 consecutive respiratory cycles (each cycle is between 3 and 10 seconds)
Respiratory Rate
The number of breaths per minute was recorded in 60 seconds.
Time frame: The number of breaths per minute was recorded in 60 seconds.
Esophageal pressure swing (Pes).
Difference between basal Pes and maximum inspiratory Pes deflection.
Time frame: 5 minutes each condition
Esophageal pressure-time product per minute (PTPes/min).
It was calculated as the area determined by esophageal deflection multiplied by respiratory rate. An ad hoc software developed in MATLAB R2018b (The MathWorks, Inc. Massachusetts, United States) was used for this purpose.
Time frame: Through study completion, an average of 24 weeks
Plan to share: Yes
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This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.
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Argentinian Intensive Care Society