An interventional study of Break of sedentary behavior with dual task and Break of sedentary behavior with walking in Aging, sponsored by University of Nove de Julho. Completed at 1 site in Brazil. Open to participants aged 60 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-04.
Sponsored by University of Nove de Julho · Not applicable, Interventional, and Other
The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people. Participants will perform, in random order, three experimental sessions (control, break with dual-task and standard break ([walk]). All sessions will have a period of 4 hours in sedentary behavior. In the standard break session and in the break session with dual-task participants will take walking and dual-task breaks every 30 minutes, and in the control session they will remain seated without breaks. Before and after this period, cerebral blood flow, vascular function, cognitive functions and blood pressure will be assessed.
University of Nove de Julho is the lead sponsor of 239 studies on the registry; 51 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 1 (13%) have results posted.
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Inclusion Criteria:
Subjects will remain seated for three hours; however, every 30 minutes the subjects will be instructed to stand and take short walks with low intensity and perform a cognitive task
Other: Break of sedentary behavior with dual task
Subjects will remain seated for three hours, however, every 30 minutes the subjects will be instructed to stand and take short walks at low intensity for two minutes,
Other: Break of sedentary behavior with walking
Subjects will remain seated for three hours
Patients will interrupt sedentary behavior performing walking and cognitive activities simultaneously
Patients will interrupt sedentary behavior performing walking
Cerebral blood velocity [centimeters per second]
Mean arterial velocity of middle cerebral artery will be measured using a transcranial doppler
Time frame: Before and 20 minutes after the intervention for 5 minutes
Cognitive function - The Trail Making Tests [seconds]
The Trail Making Tests (A and B) will be used to assess executive function and attention. Part A will determine psychomotor speed and require the participant to draw lines connecting sequentially circled numbers, such as drawing a line from 1 to 2, 2 to 3, and 3 to 4. Part B will consist of circled numbers and letters. Participants will be instructed to draw a line as quickly and as accurately as possible from 1 to A, A to 2, 2 to B, B to 3, and so on, until they complete the task. The time in seconds will be recorded in seconds after the end of each stage. After carrying out the tests, the differences between the completion times for part B - A will be calculated.
Time frame: Before and 30 minutes after the intervention
Cognitive function - Stroop test [seconds]
A computerized version of the Stroop test will be used in this study, using the Testinpacs® program. The tasks will be viewed on a notebook screen approximately 90 cm away from the participant. Answers to a set of tasks will be given as quickly as possible via two buttons. The cognitive portion of the Stroop test will be used as a psychometric test to assess cognition, being related to the executive functions of decision-making and inhibitory control exercised by the prefrontal cortex. The capacity for selective attention and response control will be estimated as the time difference between the third condition and the second condition. Smaller differences will indicate better selective attention and conflict resolution.
Time frame: Before and 32 minutes after the intervention
Cognitive function - verbal fluency [number of animal names reported]
The task will consist of recalling words that begin with the letter "F", for 60 seconds. The final score will be determined according to the number of correct words reported in 60 seconds. In the semantic modality, participants must evoke as many animals as possible in 60 seconds. The final score will be determined according to the number of animal names reported in 60 seconds.
Time frame: Before and 35 minutes after the intervention
Resting systolic and diastolic blood pressures [mmHg]
Resting systolic and diastolic blood pressures will be assessed with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan).
Time frame: Before and 10 minutes after the intervention
Resting heart rate [bpm]
Resting heart rate will be assessed with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan).
Time frame: Before and 10 minutes after the intervention
Ambulatory systolic, diastolic, and mean blood pressures monitoring [mmHg]
The systolic, diastolic, and mean blood pressures during 24 hours will be measured using a non-invasive oscillometric device (Dynamapa)
Time frame: 45 minutes after the intervention
Vascular function [%]
Vascular function will be measured with the flow-mediated dilation according to the global recommendations on popliteal artery before and after 15 minutes of intervention by a bidimensional ultrasonography device with spectral Doppler and linear transducer.
Time frame: Before and 10 minutes after the intervention
Plan to share: Yes
Supporting information: Study protocol, Sap, Analytic code
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
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University of Nove de Julho