A Phase 4 interventional study of Comparing Load and Concomitant therapy in H. Pylori Infection, sponsored by Helwan University. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2023-09-26.
Sponsored by Helwan University · Phase 4, Interventional, and Treatment
All patients who presented with epigastric pain and dyspeptic symptoms will undergo endoscopic gastric biopsies.
The patients will be subjected to: Full history taking, clinical examination, liver function tests, renal function tests, CBC, INR, abdominal ultrasonography.
About 200 patients diagnosed to have H. pylori by infection by microscopically examined, endoscopic gastric biopsies will be enrolled in our study.
All available formalin fixed and paraffin embedded tissue blocks of gastric endoscopic biopsies will be resectioned and stained with Haematoxylin and Eosin. Modified Giemsa stain, and Alcian blue/ PAS stain will be used for verification of Helicobacter pylori and demonstration of intestinal metaplasia respectively.
Biopsies will be classified using the Updated Sydney system of classification of gastritis
The patients will be randomized (closed envelopes) into one of two groups:
H. Pylori eradication will be confirmed by H. Pylori stool antigen testing at least 4 weeks after cessation of antibiotic therapy with stoppage of PPI therapy at least one to two weeks.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's enrollment of 200 is above the median of 120 across 4,200 interventional studies indexed under Infections.
Browse Infections studies →Helwan University is the lead sponsor of 69 studies on the registry; 16 are open to participants now.
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Exclusion Criteria:
Clarithro -pantoprazole- Metronidazole - Amoxicyllin
Drug: Comparing Load and Concomitant therapy
Levofloxacin -omeprazole- nitazoxanide- Doxycycline
Drug: Comparing Load and Concomitant therapy
Levofloxacin - Omeprazole - nitazoxanide - doxycycline
Also known as: Clarithromycin - pantoprazole - Metronidazole - Amoxycyllin
Eradication of H. pylori infection after treatment
Negative stool antigen test for H.pylori
Time frame: 4 weeks after end of treatment
This study is completed, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.
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Helwan University