Nano Fat Injection With or Without Fractional Carbon Dioxide Laser in Acne Scars

Browse trials for

• Atrophy 828

Atrophy

828 studies on the registry are indexed under Atrophy; 122 are open to participants now.

This study's planned enrollment of 50 is above the median of 34 across 603 interventional studies indexed under Atrophy.

Lead sponsor

Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Study arms

• Experimental
  Nano fat grafting and fractional carbon dioxide laser resurfacing

  treating of atrophic acne scars with nano fat and fractional carbon dioxide laser

  Procedure: Fat grafting

Interventions

• ProcedureFat grafting

  Nano fat grafting followed by fractional carbon dioxide laser resurfacing

  Also known as: fractional carbon dioxide laser resurfacing

Primary outcomes

1. Clinical assessment of acne scar severity

   as assessed using the Goodman and Baron Qualitative scar grading system before and after treatment on both sides of face, to determine the number of patients achieving two grades improvement vs one grade or no improvement

   Time frame: up to 24 weeks

Secondary outcomes

1. Physician global assessment

   two blinded observers will compare the before and after photographs separately on each facial side and will evaluate the improvement on a quartile grading scale as: poor,\<25% improvement; fair, 25%-50% improvement; good, 51%-75% improvement; and excellent, \>75% improvement.

   Time frame: up to 24 weeks

2. percent of reduction in scar count

   count of the total and different types of acne scars was performed, before and after treatment on both sides of the face, and the percent of reduction was calculated

   Time frame: up to 24 weeks

3. Patient satisfaction

   Patients will rate their overall satisfaction on a quartile grading system: 0, unsatisfied; 1, slightly satisfied; 2, satisfied; and 3, very satisfied

   Time frame: 1 year

4. Adverse events

   erythema, edema, crusting, pigmentary changes, ecchymosis, and scarring, will be recorded

   Time frame: 1 year

Publications

• Goodman GJ, Baron JA. Postacne scarring: a qualitative global scarring grading system. Dermatol Surg. 2006 Dec;32(12):1458-66. doi: 10.1111/j.1524-4725.2006.32354.x. PubMed 17199653 ↗
• Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol. 2001 Jul;45(1):109-17. doi: 10.1067/mjd.2001.113451. PubMed 11423843 ↗
• Chan NP, Ho SG, Yeung CK, Shek SY, Chan HH. Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians. Lasers Surg Med. 2010 Nov;42(9):615-23. doi: 10.1002/lsm.20974. PubMed 20976801 ↗

Individual participant data

Plan to share: No