Enrolling by invitationNCT05920538Updated Jun 27, 2023

Effects of Subcutaneously Infiltrated Nicardipine on the Success Rate of Radial Artety Cannulation

An interventional study of Nicardipine and Normal saline in Radial Artery Cannulation, sponsored by Mahidol University. Enrolling by invitation at 1 site in Thailand. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-06-27.

Sponsored by Mahidol University · Not applicable, Interventional, and Supportive care

From the registry’s dates

Primary completion was expected by Dec 2023, 2 years 10 months ago, but the record still lists the study as enrolling by invitation.

Phase: Not applicable
Study type: Interventional
Enrollment: 190
Allocation: Randomized
Ages: 18 Years to 75 Years
Sex: All

Study summary

The goal of this study is to compare the success rate of subcutaneously infiltrated nicardipine to normal saline in radial artery cannulation

Conditions studied

Radial Artery Cannulation

Keywords

Nicardipine
radial artery
artery cannulation
ultrasound

In context

Lead sponsor

Mahidol University is the lead sponsor of 730 studies on the registry; 118 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 75 Years
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

age 18-75 years
the patient who need to arterial line

Exclusion criteria

Exclusion Criteria:

allergy to nicardipine
history of peripheral artery disease
BMI > 40 kg/m2
unwilling to participate or denial of informed consent

Study design

Phase: Not applicable
Primary purpose: Supportive care
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Triple (Participant, Care provider, Investigator)
Enrollment: 190 participants (estimated)

Study arms

Experimental
Nicardipine
Using nicardipine 0.5 mg(0.5ml) subcutaneously infiltrated by ultrasound before redial artery cannulation.
Drug: Nicardipine
Placebo comparator
Normal saline
Using normal saline 0.5ml subcutaneously infiltrated by ultrasound before redial artery cannulation
Other: Normal saline

Interventions

DrugNicardipine
Subcutaneous infiltrate drug at puncture site by ultrasound-guided
OtherNormal saline
Subcutaneous infiltrate NSS at puncture site by ultrasound-guided

What researchers measure

Primary outcomes

Success rate of radial artery cannulation since first skin puncture
Success rate of radial artery cannulation since first skin puncture
Time frame: 10 minute from puncture at skin

Secondary outcomes

radial artery diameter
Pre-induction radial artery diameter, post-induction radial artery diameter, radial artery diameter after subcutaneous infiltration at 0,1,2 and 3 minute
Time frame: Pre-induction to 3 minute after subcutaneous infiltration
Time from first skin puncture to success cannulation
Time from first skin puncture to present of arterial wave form, assessed less than 10 minutes
Time frame: 10 minutes

Study locations

1 site

Anesthesiology Department
Bangkok, 10700, Thailand

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jun 27, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT05920538
Lead sponsor: Mahidol University
Responsible party: Sponsor
First posted: Jun 27, 2023
Start date: Mar 13, 2023
Primary completion: Dec 2023 (estimated)
Completion: Jan 2024 (estimated)
Last update: Jun 27, 2023

Study contacts

Phuriphon Songarj, MD

study director · Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

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