CClinicalTrials.gg
Enrolling by invitationNCT05892419WMLTMUpdated Jun 9, 2023

Electrophysiological Signatures of Distinct Working Memory Subprocesses That Predict Long-term Memory Success

An observational study in Memory and EEG, sponsored by University of Chicago. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2023-06-09.

Sponsored by University of Chicago · Observational

From the registry’s dates

  • Primary completion was expected by Jul 2024, 2 years 2 months ago, but the record still lists the study as enrolling by invitation.
Study type
Observational
Model
Other
Time perspective
Other
Enrollment
96
Ages
18 Years to 35 Years
Sex
All
01

Study summary

Healthy young adults will view pictures of items while the investigators record electroencephalogram (EEG) brain activity. Then, the investigators will ask the participants to report which items the participants remember seeing. The investigators will examine how the measured brain activity relates to which pictures the participants remember.

Read the detailed description

Electrophysiological signatures track distinct subprocesses of working memory, including the number of items and the spatial locations of those items. By identifying how these subprocesses predict long-term memory success in healthy young adults, this project should lead to an intricate understanding of the relationship between working memory and long-term memory. This study will investigate when and how long-term memory failures arise, by using sophisticated machine learning analyses of neural data. Moreover, this study will test the extent to which the investigators can track working memory processes in real time and how the investigators can leverage that information to improve long-term memory success. This will inform basic theories of the relationship between working memory and long-term memory and motivate future applications.

02

Conditions studied

  • Memory
  • EEG
03

In context

Lead sponsor

University of Chicago is the lead sponsor of 907 studies on the registry; 182 are open to participants now.

Of its 99 completed or terminated interventional studies of FDA-regulated products, 68 (69%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Sampling method
Non-probability sample

Study population

Healthy young adults

Inclusion criteria

  • normal or corrected to normal vision

Exclusion criteria

Exclusion Criteria:

  • non-fluent in English
05

Study design

Observational model
Other
Time perspective
Other
Enrollment
96 participants (estimated)
Patient registry
No

Interventions

  • OtherNo intervention

    There is no intervention

06

What researchers measure

Primary outcomes

  1. Memory performance

    To measure recognition memory performance, participants will view pictures and respond as to whether they remember previously seeing these items. Participants will be shown both old and new items. In the long-term memory phase, they will report their confidence at having seen each image using a four point rating scale, ranging from being confident the item is new (i.e., not previously seen) to being confident the item is old (i.e., previously seen).

    Time frame: This task is performed multiple time within the experimental session, which in total lasts around 3 hours.

07

Study locations

1 site
  • University of Chicago
    Chicago, Illinois 60637, United States
08

References and documents

Individual participant data

Plan to share: Yes — The investigators will post de-identified data online on scientific repositories including the Open Science Framework (online), zenodo or github, so that anonymized data will be made available to outside researchers. Shared data will include, at a minimum, csv or text files that summarize participants performance. Any computer scripts or stimuli used for task development also will be shared.

Supporting information: Analytic code

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 9, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05892419
Lead sponsor
University of Chicago
Responsible party
Sponsor
First posted
Jun 7, 2023
Start date
Jul 1, 2022
Primary completion
Jul 31, 2024 (estimated)
Completion
Jul 31, 2026 (estimated)
Last update
Jun 9, 2023

Study contacts

Megan deBettencourt
principal investigator · University of Chicago
Ed Vogel
principal investigator · University of Chicago
Ed Awh
principal investigator · University of Chicago

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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