An interventional study of exercise and nutritional support in Sarcopenia, sponsored by Chungnam National University Hospital. Recruiting at 1 site in South Korea. Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-03-18.
Sponsored by Chungnam National University Hospital · Not applicable, Interventional, and Treatment
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis. The investigators have already recognized the sarcopenia-associated mortality and morbidity in patients with hemodialysis. However, intervention studies on hemodialysis patients with sarcopenia have not been conducted until now. In 2021, the investigators conducted a pilot study to evaluate the effectiveness of the combined exercise and nutrition intervention for sarcopenia in patients with hemodialysis to confirm the effectiveness. This study is a follow-up study, conducted as a randomized controlled trial.
This is a prospective, 1:1 randomized controlled study with 40 patients with hemodialysis who were diagnosed as sarcopenia or frailty in our previous cohort study. Combined intervention will consist of resistance exercise and nutritional supplementation for 12 weeks. The primary outcome of this study is muscle mass and handgrip strength after 12 weeks' intervention. All functional outcomes will be measured at 0, 4, 8 and 12 weeks after intervention. The data will be analysed using the intention-to-treat principle.
1,208 studies on the registry are indexed under Sarcopenia; 402 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 775 interventional studies indexed under Sarcopenia.
Browse Sarcopenia studies →Chungnam National University Hospital is the lead sponsor of 20 studies on the registry; 11 are open to participants now.
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Exclusion Criteria:
resistance exercise and protein supplementation including branched chain amino acids for 12 weeks
Other: exercise and nutritional support
No intervention, but the same measurements as the experimental group are conducted.
resistance exercise and protein supplementation including branched chain amino acids for 12 weeks
Handgrip strength in Kg using a portable dyanometer
Measurement of handle strength using a portable dynamometer to view the function of skeletal muscle every 4 weeks.
Time frame: 12 weeks
Body composition using dual energy x-ray absorptiometry (DXA)
Body composition will be evaluated by dual energy x-ray absorptiometry at start and end of the study.
Time frame: 12 weeks
Body composition using body composition monitor (BCM)
Body composition will be evaluated by bioimpedence analysis using body composition monitor start at and end of the study.
Time frame: 12 weeks
The total score of Short Physical Performance Battery(SPPB)
The total score is the sum of 5 times Chair Stand Test(CST) score and balance test score and gait speed test score for 4meter.
Time frame: 12 weeks
The second of 5 times Chair Stand Test
Pre test, participants fold their arms across their chest and try to stand up once from a chair. And Measures the time required to perform five rises from a chair to an upright position as fast as possible without the use of the arms.
Time frame: 12 weeks
skeletal muscle mass index(SMI) in cm2/m2
The SMI was calculated according to the following formula: skeletal muscle mass (cm 2) / height 2 (m 2).
Time frame: 12 weeks
Glucose pattern using continuous glucose monitoring system(freestyle libre)
Blood glucose is measured using continuous glucose monitoring system(freestyle libre) at start and end of the study.
Time frame: 12 weeks
Plan to share: No
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Chungnam National University Hospital