CClinicalTrials.gg
CompletedNCT05878080Updated Feb 25, 2026Results posted

iTBS/fMRI Study of Hierarchical Control in the PFC

An interventional study of transcranial magnetic stimulation in Transcranial Magnetic Stimulation, sponsored by Florida State University. Completed at 2 sites in United States. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-25.

Sponsored by Florida State University · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
54
Allocation
Randomized
Ages
18 Years to 30 Years
Sex
All
01

Study summary

The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.

Read the detailed description

The Comprehensive Control Task (CCT) was designed to examine hierarchical control in a single, well-controlled factorial task. On each trial, participants view a letter surrounded by a colored shape at a particular screen location. Color cues the relevant feature, letter or location, for a block of trials. The first trial of a block requires a decision of whether the stimulus is the first position of a circular sequence (sequence start). Subsequent trials require a decision of whether the viewed stimulus follows the previous stimulus in a circular sequence (sequence 1-back). The letter sequence (T-A-B-L-E-T) and spatial sequence (Top-Bottom Right-Left-Right-Bottom Left-Top) are difficulty-matched.

Shape cues the task to perform. Squares indicate the standard baseline task, and each block begins and ends with baseline trials. Different shapes indicate sub-tasks. In Switching blocks, shape-switches (e.g. from square to circle or circle to square) cue the sequence start task. Shape-repeats cue the sequence 1-back task. In Planning blocks, triangle shapes indicate that the stimulus can be ignored (automatic "no" response). All the while, the last square-shaped stimulus must be retained as a reference for the next square-shaped stimulus. Finally, in Dual blocks, diamond shapes indicate switching (sequence start) and also planning. The reversion back to square shapes requires sequence matching to the distal, previous square.

The design is factorial with stimulus-domain x contextual control x temporal control orthogonally manipulated. Full details of the CCT have been previous described in Nee \& D'Esposito, 2016; 2017.

The focus in this study will be comparison of FPl-TMS, MFG-TMS, and S1-TMS in an interleaved fMRI-TMS-fMRI design. The logic is to test the apical status of the FPl/MFG through the extent to which TMS impacts other PFC areas and behavior.

Each experiment will begin with 1 session of the CCT with fMRI to localize PFC targets. Each participant will then perform 3 counter-balanced sessions wherein a different site will be targeted by TMS followed immediately by fMRI on the CCT.

02

Conditions studied

  • Transcranial Magnetic Stimulation
03

In context

Lead sponsor

Florida State University is the lead sponsor of 241 studies on the registry; 46 are open to participants now.

Of its 15 completed or terminated interventional studies of FDA-regulated products, 9 (60%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Between the ages of 18 and 30
  • Right-handed
  • Native English speaker or fluent by the age of 6

Exclusion criteria

Exclusion Criteria:

  • History of psychiatric disorders
  • History of neurological disorders
  • Receiving medications for psychiatric or neurological disorders
  • Familial history of epilepsy
  • Taking any drugs or medications that are pro-epileptic
  • Metal anywhere in the head excluding the mouth
  • Tinnitus
  • Women who are pregnant
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
54 participants (actual)

Study arms

  • Experimental
    FPl-TMS

    Transcranial magnetic stimulation to the lateral frontal pole. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.

    Device: transcranial magnetic stimulation

  • Experimental
    MFG-TMS

    Transcranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.

    Device: transcranial magnetic stimulation

  • Active comparator
    S1-TMS

    Transcranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.

    Device: transcranial magnetic stimulation

Interventions

  • Devicetranscranial magnetic stimulation

    Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.

06

What researchers measure

Primary outcomes

  1. PFC-PPC Effective Connectivity

    effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units, but effective connectivity is a rate measure, so is expressed in Hertz\]

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

  2. PFC-PPC Activation

    blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units\]

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

Secondary outcomes

  1. Temporal Control Performance (Error Rate)

    behavioral performance (error rate) on conditions involving temporal control in the comprehensive control task

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

  2. Contextual Control Performance (Error Rate)

    behavioral performance (error rate) on conditions involving contextual control in the comprehensive control task

    Time frame: baseline, pre-intervention and immediately after intervention (t minutes to 1 hour post-TMS)

  3. Temporal x Contextual Control Performance (Error Rate)

    behavioral performance (error rate) of the interaction of temporal and contextual control in the comprehensive control task

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

  4. Temporal Control Performance (Reaction Time)

    behavioral performance (reaction time in milliseconds) on conditions involving temporal control in the comprehensive control task

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

  5. Contextual Control Performance (Reaction Time)

    behavioral performance (reaction time in milliseconds) on conditions involving contextual control in the comprehensive control task

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

  6. Temporal x Contextual Control Performance (Reaction Time)

    behavioral performance (reaction time in milliseconds) on the interaction between temporal control and contextual control in the comprehensive control task

    Time frame: baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)

07

Results

Posted Feb 25, 2026

Participant flow

Participant flow — Overall Study
MilestoneMFG-TMS Then FPl-TMS Then S1-TMSMFG-TMS Then S1-TMS Then FPl-TMSFPl-TMS Then MFG-TMS Then S1-TMSFPl-TMS Then S1-TMS Then MFG-TMSS1-TMS Then MFG-TMS Then FPl-TMSS1-TMS Then FPl-TMS Then MFG-TMS
Started668658
Completed656556
Not completed012102
Withdrew: Withdrawal by subject000001
Withdrew: Tms intolerance012101

Outcome measures

PrimaryPFC-PPC Effective Connectivity

effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units, but effective connectivity is a rate measure, so is expressed in Hertz\]

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · Hertz
PFC-PPC Effective Connectivity
HertzFPl-TMSMFG-TMSS1-TMS
MFG Efferent Connectivity Overall Magnitude0.2177 ± 0.02680.2248 ± 0.03360.1911 ± 0.0317
MFG Efferent Connectivity to Temporal Control Areas Magnitude0.3157 ± 0.03310.3168 ± 0.05330.3153 ± 0.038
MFG Efferent Connectivity to Contextual Control Areas Magnitude0.1198 ± 0.03690.1327 ± 0.04970.067 ± 0.0446
FPl Efferent Connectivity Overall Magnitude0.0738 ± 0.02390.0653 ± 0.03030.1078 ± 0.0293
FPl Efferent Connectivity to Temporal Control Areas Magnitude0.1212 ± 0.08990.0865 ± 0.07170.0992 ± 0.0828
FPl Efferent Connectivity to Contextual Control Areas Magnitude0.0508 ± 0.03450.0479 ± 0.03970.0946 ± 0.0396
FPl Efferent Connectivity to Sensorimotor Control Areas Magnitude0.0952 ± 0.03960.0964 ± 0.0420.156 ± 0.0579
MFG Efferent Connectivity Overall Magnitude Change from Baseline0.008 ± 0.0320.015 ± 0.0189-0.0186 ± 0.0185
MFG Efferent Connectivity to Temporal Control Areas Magnitude Change from Baseline-0.0056 ± 0.0264-0.0045 ± 0.0306-0.006 ± 0.0314
MFG Efferent Connectivity to Contextual Control Areas Magnitude Change from Baseline0.0216 ± 0.06020.0346 ± 0.031-0.0311 ± 0.0291
FPl Efferent Connectivity Overall Magnitude Change from Baseline-0.00089 ± 0.0204-0.0093 ± 0.03180.0332 ± 0.0234
FPl Efferent Connectivity to Temporal Control Areas Magnitude Change from Baseline-0.0228 ± 0.0718-0.0575 ± 0.0476-0.0449 ± 0.0681
FPl Efferent Connectivity to Contextual Control Areas Magnitude Change from Baseline0.0121 ± 0.02510.0092 ± 0.04030.0559 ± 0.028
FPl Efferent Connectivity to Sensorimotor Control Areas Magnitude Change from Baseline-0.0178 ± 0.0282-0.0166 ± 0.03480.043 ± 0.0508
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.599
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.685
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.396
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.68
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.527
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.601
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.266
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.73
PrimaryPFC-PPC Activation

blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units\]

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · No Unit
PFC-PPC Activation
No UnitFPl-TMSMFG-TMSS1-TMS
Overall BOLD0.1649 ± 0.0190.174 ± 0.01770.1721 ± 0.0198
Overall BOLD in Temporal Control Subsystem0.0796 ± 0.02570.0958 ± 0.01990.1021 ± 0.0209
Overall BOLD in Contextual Control Subsystem0.2405 ± 0.02750.239 ± 0.0240.2402 ± 0.0282
Overall BOLD in Sensorimotor Control Subsystem0.1748 ± 0.01620.1871 ± 0.01980.1738 ± 0.0199
Temporal Control BOLD in Temporal Control Subsystem0.2512 ± 0.03820.2482 ± 0.03510.26 ± 0.0414
Temporal Control BOLD in Contextual Control Subsystem0.1159 ± 0.03250.1414 ± 0.03050.1039 ± 0.0377
Temporal Control BOLD in Sensorimotor Control Subsystem-0.0366 ± 0.0247-0.0044 ± 0.0223-0.0043 ± 0.0264
Contextual Control BOLD in Temporal Control Subsystem0.1324 ± 0.04290.0525 ± 0.03880.1156 ± 0.042
Contextual Control BOLD in Contextual Control Subsystem0.3907 ± 0.04220.2856 ± 0.04450.3423 ± 0.0489
Contextual Control BOLD in Sensorimotor Control Subsystem0.2846 ± 0.02210.2389 ± 0.03720.2328 ± 0.0283
Temporal x Contextual Control BOLD in Temporal Control Subsystem-0.1448 ± 0.0334-0.0133 ± 0.0347-0.0692 ± 0.0339
Temporal x Contextual Control BOLD in Contextual Control Subsystem0.2149 ± 0.03690.2899 ± 0.03160.2748 ± 0.0369
Temporal x Contextual Control BOLD in Sensorimotor Control Subsystem0.2762 ± 0.02960.3269 ± 0.02930.2929 ± 0.033
Overall BOLD Change from Baseline0.0318 ± 0.01520.0409 ± 0.01540.0389 ± 0.017
Overall BOLD in Temporal Control Subsystem Change from Baseline0.0164 ± 0.01990.0326 ± 0.01690.039 ± 0.0166
Overall BOLD in Contextual Control Subsystem Change from Baseline0.0459 ± 0.02020.0444 ± 0.02330.0457 ± 0.0247
Overall BOLD in Sensorimotor Control Subsystem Change from Baseline0.0331 ± 0.01240.0455 ± 0.01440.0322 ± 0.0154
Temporal Control BOLD in Temporal Control Subsystem Change from Baseline-0.0335 ± 0.043-0.0365 ± 0.0326-0.0247 ± 0.0299
Temporal Control BOLD in Contextual Control Subsystem Change from Baseline0.0632 ± 0.04090.0887 ± 0.03140.051 ± 0.0353
Temporal Control BOLD in Sensorimotor Control Subsystem Change from Baseline0.0364 ± 0.030.0686 ± 0.02330.0686 ± 0.0285
Contextual Control BOLD in Temporal Control Subsystem Change from Baseline0.1002 ± 0.02980.0202 ± 0.03790.0833 ± 0.0427
Contextual Control BOLD in Contextual Control Subsystem Change from Baseline0.0423 ± 0.0236-0.0628 ± 0.0482-0.0061 ± 0.0448
Contextual Control BOLD in Sensorimotor Control Subsystem Change from Baseline0.0084 ± 0.0165-0.0373 ± 0.0327-0.0434 ± 0.03
Temporal x Contextual Control BOLD in Temporal Control Subsystem Change from Baseline-0.0173 ± 0.03490.1141 ± 0.03470.0582 ± 0.0284
Temporal x Contextual Control BOLD in Contextual Control Subsystem Change from Baseline0.0323 ± 0.03670.1073 ± 0.03240.0922 ± 0.0372
Temporal x Contextual Control BOLD in Sensorimotor Control Subsystem Change from Baseline0.0546 ± 0.02880.1052 ± 0.02230.0713 ± 0.0222
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.083
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.633
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.606
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.171
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.001
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.002
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.004
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.165
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.888
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.668
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.874
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.124
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.03
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.406
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.168
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.148
SecondaryTemporal Control Performance (Error Rate)

behavioral performance (error rate) on conditions involving temporal control in the comprehensive control task

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · Percentage of errors
Temporal Control Performance (Error Rate)
Percentage of errorsFPl-TMSMFG-TMSS1-TMS
Difference between high and low temporal control trials error roate3.6774 ± 0.79654.6272 ± 0.86953.9773 ± 0.932
Difference between high and low temporal control sub-task trial error rate-0.9785 ± 0.6280.0688 ± 0.5453-0.7576 ± 0.5464
Difference between high and low temporal control return trial error rate8.3333 ± 1.59579.1856 ± 1.67648.7121 ± 1.9221
Difference between high and low temporal control trials error rate relative to baseline-0.4939 ± 0.82290.4559 ± 1.0711-0.1941 ± 0.9148
Difference between high and low temporal control sub-task trial error rate relative to baseline-0.0156 ± 0.66391.0317 ± 0.65440.2053 ± 0.518
Difference between high and low temporal control return trial error rate relative to baseline-0.9722 ± 1.4047-0.1199 ± 2.1866-0.5934 ± 1.711
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.788
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.909
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.602
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.985
SecondaryContextual Control Performance (Error Rate)

behavioral performance (error rate) on conditions involving contextual control in the comprehensive control task

Time frame:
baseline, pre-intervention and immediately after intervention (t minutes to 1 hour post-TMS)
Reported as:
Mean · Percent Errors
Contextual Control Performance (Error Rate)
Percent ErrorsFPl-TMSMFG-TMSS1-TMS
Difference between high and low contextual control trial error rate7.7178 ± 1.21484.7408 ± 0.84935.7449 ± 1.2389
Difference between high and low contextual control sub-task trial error rate2.5568 ± 0.63322.3794 ± 0.43842.399 ± 0.6224
Difference between high and low contextual control return trial error rate12.8788 ± 2.3037.1023 ± 1.519.0909 ± 2.1519
Difference between high and low contextual control trial error rate relative to baseline1.1336 ± 1.1381-1.8434 ± 0.8927-0.8393 ± 1.1115
Difference between high and low contextual control sub-task trial error rate relative to baseline0.0828 ± 0.6901-0.0946 ± 0.5645-0.075 ± 0.6446
Difference between high and low contextual control return trial error rate relative to baseline2.1843 ± 2.1215-3.5922 ± 1.5391-1.6035 ± 1.9302
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.119
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.046
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.098
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.007
SecondaryTemporal x Contextual Control Performance (Error Rate)

behavioral performance (error rate) of the interaction of temporal and contextual control in the comprehensive control task

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · Percentage Errors
Temporal x Contextual Control Performance (Error Rate)
Percentage ErrorsFPl-TMSMFG-TMSS1-TMS
Interaction contrast of temporal and contextual control on error rate-0.2367 ± 0.9101-0.4449 ± 0.8262-0.5051 ± 1.0789
Interaction contrast of temporal and contextual control on error rate on sub-task trials2.5568 ± 0.56822.0457 ± 0.5512.5884 ± 0.5051
Interaction contrast of temporal and contextual control on error rate on return trials-3.0303 ± 1.9015-2.9356 ± 1.7413-3.5985 ± 2.168
Interaction contrast of temporal and contextual control on error rate relative to baseline0.2806 ± 0.8250.0724 ± 0.81320.0122 ± 0.9786
Interaction contrast of temporal and contextual control on error rate on sub-task trials vs baseline0.8515 ± 0.60160.3404 ± 0.5130.8831 ± 0.6663
Interaction contrast of temporal and contextual control on error rate on return trials vs baseline-0.2904 ± 1.4981-0.1957 ± 1.6377-0.8586 ± 1.7872
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.985
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.818
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.972
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.878
SecondaryTemporal Control Performance (Reaction Time)

behavioral performance (reaction time in milliseconds) on conditions involving temporal control in the comprehensive control task

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · Milliseconds
Temporal Control Performance (Reaction Time)
MillisecondsFPl-TMSMFG-TMSS1-TMS
Difference between high and low temporal control trial reaction time14.7162 ± 12.63021.3866 ± 13.06872.3381 ± 14.4946
Difference between high and low temporal control sub-task trial reaction time-49.5445 ± 12.9196-49.5869 ± 14.5006-65.4566 ± 13.2162
Difference between high and low temporal control return trial reaction time78.977 ± 19.973352.3601 ± 17.903770.1329 ± 23.4219
Difference between high and low temporal control trial reaction time relative to baseline17.1732 ± 11.86953.8436 ± 10.86244.7951 ± 12.1586
Difference between high and low temporal control sub-task trial reaction time relative to baseline22.1352 ± 10.435622.0929 ± 11.38126.2231 ± 7.7173
Difference between high and low temporal control return trial reaction time relative to baseline12.2112 ± 18.1079-14.4056 ± 17.81383.3671 ± 21.5217
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.567
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.364
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.611
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.389
SecondaryContextual Control Performance (Reaction Time)

behavioral performance (reaction time in milliseconds) on conditions involving contextual control in the comprehensive control task

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · Milliseconds
Contextual Control Performance (Reaction Time)
MillisecondsFPl-TMSMFG-TMSS1-TMS
Difference between high and low contextual control trial reaction time223.8835 ± 13.897196.5144 ± 16.5796207.0607 ± 12.3121
Difference between high and low contextual control sub-task trial reaction time185.165 ± 11.2663151.2204 ± 12.6028172.9899 ± 13.9
Difference between high and low contextual control return trial reaction time262.6019 ± 22.2582241.8084 ± 24.9603241.1315 ± 19.2476
Difference between high and low contextual control trial reaction time relative to baseline-8.7656 ± 14.3625-36.1347 ± 17.6706-25.5884 ± 12.5704
Difference between high and low contextual control sub-task trial reaction time relative to baseline-20.5084 ± 11.4171-54.453 ± 13.4582-32.6835 ± 11.8063
Difference between high and low contextual control return trial reaction time relative to baseline2.9771 ± 22.6942-17.8164 ± 28.1807-18.4993 ± 20.0323
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.078
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.534
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.194
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.746
SecondaryTemporal x Contextual Control Performance (Reaction Time)

behavioral performance (reaction time in milliseconds) on the interaction between temporal control and contextual control in the comprehensive control task

Time frame:
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Reported as:
Mean · Milliseconds
Temporal x Contextual Control Performance (Reaction Time)
MillisecondsFPl-TMSMFG-TMSS1-TMS
Interaction contrast of temporal control x contextual control trials on reaction time73.9891 ± 17.204962.1515 ± 11.334473.5031 ± 12.0316
Interaction contrast of temporal control x contextual control sub-task trials on reaction time174.2524 ± 18.1531157.9577 ± 15.4228161.0199 ± 13.3624
Interaction contrast of temporal control x contextual control return trials on reaction time-26.2741 ± 27.3581-33.6546 ± 18.6431-14.0137 ± 21.2459
Interaction contrast of temporal control x contextual control trials on reaction time vs baseline14.056 ± 17.98292.2184 ± 10.630313.5699 ± 11.4938
Interaction contrast of temporal control x contextual control sub-task trials on RT vs baseline2.6641 ± 15.6154-13.6306 ± 14.4518-10.5684 ± 12.8136
Interaction contrast of temporal control x contextual control return trials on RT vs baseline25.4479 ± 25.72118.0674 ± 15.35337.7083 ± 21.3244
Statistical analysis
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.621
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.33
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.663
  • FPl-TMS vs MFG-TMS vs S1-TMS · ANOVA · p = 0.611

Adverse events

Collected over From enrollment until end of participation, up to 6 weeks. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
FPl-TMS0/37 (0%)0/37 (0%)4/37 (10.8%)
MFG-TMS0/34 (0%)0/34 (0%)1/34 (2.9%)
S1-TMS0/35 (0%)0/35 (0%)0/35 (0%)
Most frequent other events
Most frequent other events
EventFPl-TMSMFG-TMSS1-TMS
Scalp discomfortSkin and subcutaneous tissue disorders4/371/340/35

Baseline characteristics

Age, Categorical
Age, Categorical(Participants)MFG-TMS Then FPl-TMS Then S1-TMSMFG-TMS Then S1-TMS Then FPl-TMSFPl-TMS Then MFG-TMS Then S1-TMSFPl-TMS Then S1-TMS Then MFG-TMSS1-TMS Then MFG-TMS Then FPl-TMSS1-TMS Then FPl-TMS Then MFG-TMSTotal
<=18 years0000000
Between 18 and 65 years66865839
>=65 years0000000
Age, Continuous
Age, Continuous(years)MFG-TMS Then FPl-TMS Then S1-TMSMFG-TMS Then S1-TMS Then FPl-TMSFPl-TMS Then MFG-TMS Then S1-TMSFPl-TMS Then S1-TMS Then MFG-TMSS1-TMS Then MFG-TMS Then FPl-TMSS1-TMS Then FPl-TMS Then MFG-TMSTotal
Mean19.5 (18 to 22)20 (18 to 23)20 (18 to 23)19.67 (18 to 22)19.6 (18 to 21)20 (18 to 25)19.8 (18 to 25)
Sex: Female, Male
Sex: Female, Male(Participants)MFG-TMS Then FPl-TMS Then S1-TMSMFG-TMS Then S1-TMS Then FPl-TMSFPl-TMS Then MFG-TMS Then S1-TMSFPl-TMS Then S1-TMS Then MFG-TMSS1-TMS Then MFG-TMS Then FPl-TMSS1-TMS Then FPl-TMS Then MFG-TMSTotal
Female43663729
Male23202110
Race (NIH/OMB)
Race (NIH/OMB)(Participants)MFG-TMS Then FPl-TMS Then S1-TMSMFG-TMS Then S1-TMS Then FPl-TMSFPl-TMS Then MFG-TMS Then S1-TMSFPl-TMS Then S1-TMS Then MFG-TMSS1-TMS Then MFG-TMS Then FPl-TMSS1-TMS Then FPl-TMS Then MFG-TMSTotal
American Indian or Alaska Native0000101
Asian1121027
Native Hawaiian or Other Pacific Islander0000000
Black or African American1110014
White43354524
More than one race0120003
Unknown or Not Reported0000000
Ethnicity (NIH/OMB)
Ethnicity (NIH/OMB)(Participants)MFG-TMS Then FPl-TMS Then S1-TMSMFG-TMS Then S1-TMS Then FPl-TMSFPl-TMS Then MFG-TMS Then S1-TMSFPl-TMS Then S1-TMS Then MFG-TMSS1-TMS Then MFG-TMS Then FPl-TMSS1-TMS Then FPl-TMS Then MFG-TMSTotal
Hispanic or Latino1030127
Not Hispanic or Latino56564632
Unknown or Not Reported0000000
08

Study locations

2 sites
  • Florida State University Psychology Department Building
    Tallahassee, Florida 32303, United States
  • FSU MRI Facility
    Tallahassee, Florida 32306, United States
09

References and documents

Study documents

  • Protocol and statistical analysis plan · Jul 1, 2024
  • Informed consent form · Jun 13, 2023

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: Yes — Behavioral and imaging data will be shared

Supporting information: Analytic code

10

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
11

Registry details

Key details

Study ID
NCT05878080
Lead sponsor
Florida State University
Collaborators
National Institute of Mental Health (NIMH)
Responsible party
Derek Nee (Associate Professor, Florida State University) — Principal investigator
First posted
May 26, 2023
Start date
May 15, 2023
Primary completion
Dec 2, 2024
Completion
Dec 2, 2024
Results posted
Feb 25, 2026
Last update
Feb 25, 2026

Study contacts

Derek E Nee, PhD
principal investigator · Florida State University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.

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