An interventional study of Placebo and Mitoquinone Mesylate in Aging, Endothelial Dysfunction and Cardiovascular Function, sponsored by Ball State University. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-05-24.
Sponsored by Ball State University · Not applicable, Interventional, and Other
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.
Ball State University is the lead sponsor of 13 studies on the registry; 9 are open to participants now.
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Exclusion Criteria:
Gelatin capsules
Dietary Supplement: Placebo
Capsules containing mitoquinone mesylate (MitoQ, 5 mg/capsule) totaling 80 mg were taken once.
Dietary Supplement: Mitoquinone Mesylate
Gelatin capsules
MitoQ was given once (single dose, 80 mg)
Also known as: MitoQ
Change in vascular endothelial function
Brachial artery flow-mediated dilation (% \[relative\] and mm \[absolute\])
Time frame: Baseline and Post 1 hour
Change in cardiovascular function
Subendocardial viability ratio (%)
Time frame: Baseline and Post 1 hour
Change in Aortic Stiffness
Carotid-femoral pulse wave velocity (meters/second)
Time frame: Baseline and Post 1 hour
Change in carotid artery stiffness - beta-stiffness index
Carotid artery Beta stiffness index (AU)
Time frame: Baseline and Post 1 hour
Change in carotid artery compliance
Carotid artery compliance (mmHg/mm\^2)
Time frame: Baseline and Post 1 hour
Change in carotid artery distensibility
Carotid artery distensibility (10\^-3/kilopascals)
Time frame: Baseline and Post 1 hour
Change in carotid artery Young's elastic modulus
Carotid artery Young's elastic modulus (kilopascals, kPa)
Time frame: Baseline and Post 1 hour
Plan to share: No
This study is completed, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Mitoquinone
Ball State University