An observational study in Anti-endometrial Antibodies, sponsored by South Valley University. Active, not recruiting at 1 site in Egypt. Open to female participants aged 15 Years to 35 Years. Per ClinicalTrials.gov, last updated 2023-05-09.
Sponsored by South Valley University · Observational
The aims of this study is to asses the predictive value of serum anti_endometrial antibodies in prediction of implantation rate in patient with endometriosis who undergoing intracytoplasmic sperm injection cycles.
prospective cohort study of infertile patients ( with endometriosis \& adenomyosis) who will undergo ICSI cycles at the assisted reproduction units,Obstetrics and Gynacology departments , South Valley University and Cairo University.
Initial evaluation: this will include:
Evaluation of male factor (husbnad semen analysis)
Eligible women will undergo :
Intracytoplasmic sperm injection (ICSI) gonadotrophin stimulation drugs will be used, individualization of stimulation dose and slight modifications will be done according to ovarian response. Proper protocol will be used. Baseline assessment of AFC by transvaginal scans wasill be performed by experienced gynaecologist using a 7.5 MHz vaginal probe 7-MHz (Samsung, Korea). Ovarian response monitoring to stimulation drug, estimation the doses of gonadotrophins required for follicular growing and maturation, assessment the stimulation time in days till time of ovum pick-up, and the number and quality of oocytes obtained will be recorded in and analysed at the end of the study. When 3-4 follicles acquired >18 mm ,triggering of ovulation will be done using human chorionic gonadotrophins 36 hours prior to pick-up of oocytes. after oocyte retrieval ICSI procedure will be done for all cases. embryos will be transferred to each mother on day 3 or day 5 according to embryos quality and remaining of good quality embryos will be frozen for subsequent transfer. Luteal support started in day of ova pick up till date of pregnancy test (14 days post embryos transfer)
Research outcome measures:
a. Primary (main):
901 studies on the registry are indexed under Endometriosis; 259 are open to participants now.
This study's planned enrollment of 30 is below the median of 128 across 344 observational studies indexed under Endometriosis.
Browse Endometriosis studies →South Valley University is the lead sponsor of 147 studies on the registry; 46 are open to participants now.
Counted across the registry records on this site, refreshed daily.
infertile patients ( with endometriosis \& adenomyosis) who will undergo ICSI cycles at the assisted reproduction units,Obstetrics and Gynacology departments , South Valley University and Cairo University.
Exclusion Criteria:
Patients will not be eligible for this study if:
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- Take blood samples from patients to measure anti-endometrial antibody concentrations in the serum of women with endometriosis using human Endometrium Antibody, EMAb ELISA Kit .This assay employs the qualitative enzyme immunoassay technique
serum antiendometrial antibodies and implantation rate in patient with endometriosis who undergoing intracytoplasmic sperm injection cycles
assess the predictive value of serum antiendometrial antibodies in prediction of implantation rate in patient with endometriosis who undergoing intracytoplasmic sperm injection cycles
Time frame: baseline
serum antiendometrial antibodies in patient with endometriosis who undergoing intracytoplasmic sperm injection cycles and egg quality retrieved
find correlation between serum anti-endometrial antibodies and egg quality retrieved
Time frame: baseline
This study is active, not recruiting, as verified in May 2023. You cannot join it, but the record below documents what was studied.
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South Valley University