An interventional study of food (breakfast) in Obesity and Appetitive Behavior, sponsored by Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri. Completed at 1 site in Argentina. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-04-18.
Sponsored by Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri · Not applicable, Interventional, and Prevention
The present study aims to evaluate in adults with normal weight and with overweight or obesity who live in the city of La Plata the circulating levels of various hormones that regulate appetite and the gene expression of their receptors in peripheral blood mononuclear cells before and after food intake.
the investigators plan a single test meal study in males and females with normal weight (NW) or overweight/obesity (OW/OB) assessing whether plasma appetite regulatory hormones levels are associated with different metabolic and anthropometric variables as well as with appetite sensations.
Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri is the lead sponsor of 4 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Pregnancy
the breakfast composition is 56 kcal% carbohydrates, 12 kcal% protein and 34 kcal% lipids and comprises yogurt, cereals and almonds
Dietary Supplement: food (breakfast)
The breakfast composition is 56 kcal% carbohydrates, 12 kcal% protein and 34 kcal% lipids and comprises yogurt, cereals and almonds
plasma ghrelin concentration
ghrelin concentration (fmol/ml)
Time frame: pre -prandial
plasma leptin concentration
leptin concentration (ug/ml)
Time frame: pre -prandial
plasma glucagon-like peptide 1 concentration
glucagon-like peptide 1 concentration (ug/ml)
Time frame: pre -prandial
plasma liver antimicrobial peptide 2 concentration
liver antimicrobial peptide 2 concentration (pmol/ml)
Time frame: pre -prandial
plasma des-acyl ghrelin concentration
des-acyl ghrelin concentration (fmol/ml)
Time frame: pre -prandial
plasma ghrelin concentration
ghrelin concentration (fmol/ml)
Time frame: 1 hour post -prandial
plasma leptin concentration
leptin concentration (ug/ml)
Time frame: 1 hour post -prandial
plasma glucagon-like peptide 1 concentration
glucagon-like peptide 1 concentration (ug/ml)
Time frame: 1 hour post -prandial
plasma liver antimicrobial peptide 2 concentration
liver antimicrobial peptide 2 concentration (pmol/ml)
Time frame: 1 hour post -prandial
plasma des-acyl ghrelin concentration
des-acyl ghrelin concentration (fmol/ml)
Time frame: 1 hour post -prandial
plasma glucose concentration
glucose concentration (mg%)
Time frame: pre -prandial
plasma glucose concentration
glucose concentration (mg%)
Time frame: 1 hour post -prandial
plasma triglycerides concentration
triglycerides concentration (mg%)
Time frame: pre-prandial
plasma triglycerides concentration
triglycerides concentration (mg%)
Time frame: 1 hour post -prandial
plasma total cholesterol concentration
total cholesterol concentration (mg%)
Time frame: pre -prandial
plasma total cholesterol concentration
total cholesterol concentration (mg%)
Time frame: 1 hour post -prandial
ghrelin proteolysis
plasma proteolytic activity of ghrelin (relative units)
Time frame: pre -prandial
ghrelin proteolysis
plasma proteolytic activity of ghrelin (relative units)
Time frame: 1 hour post -prandial
ghrelin deacylation
plasma desacylase actvitity of ghrelin (relative units)
Time frame: pre -prandial
ghrelin deacylation
plasma desacylase actvitity of ghrelin (relative units)
Time frame: 1 hour post -prandial
leptin receptor gene expression in peripheral blood mononuclear cells
leptin receptor gene expression in peripheral blood mononuclear cells (relative expression)
Time frame: pre-prandial
insulin receptor gene expression in peripheral blood mononuclear cells
insulin receptor gene expression in peripheral blood mononuclear cells (relative expression)
Time frame: pre-prandial
ghrelin receptor gene expression in peripheral blood mononuclear cells
ghrelin receptor gene expression in peripheral blood mononuclear cells (relative expression)
Time frame: pre-prandial
hunger sensation
visual analog scale (cm)
Time frame: pre-prandial and 15, 30, 45 and 60 min post-prandial
fullness sensation
visual analog scale (cm)
Time frame: pre-prandial and 15, 30, 45 and 60 min post-prandial
"desire to eat" sensation
visual analog scale (cm)
Time frame: pre-prandial and 15, 30, 45 and 60 min post-prandial
"prospective food consumption" sensation
visual analog scale (cm)
Time frame: pre-prandial and 15, 30, 45 and 60 min post-prandial
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.
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Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri