An interventional study of Epigallocatechin gallate (EGCG) and Sodium hypochlorite (NaOCl) in Irreversible Pulpitis, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 17 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-08-24.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This study evaluates the effect of two flushing agents (epigallocatechin gallate (EGCG) and sodium hypochlorite (NaOCl)) during full pulpotomy using two different calcium silicate-based materials (MTA and premixed bioceramic putty) on postoperative pain, success rate and dentin bridge formation in mature permanent mandibular molars with irreversible pulpitis. Participants will be divided into four groups based on the flushing fluid and the pulp capping material to be used.
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Mature permanent mandibular molars with:
Exclusion Criteria:
Other: Epigallocatechin gallate (EGCG) · Other: Mineral trioxide aggregate (MTA)
Other: Epigallocatechin gallate (EGCG) · Other: Premixed bioceramic putty
Other: Sodium hypochlorite (NaOCl) · Other: Premixed bioceramic putty
Other: Sodium hypochlorite (NaOCl) · Other: Mineral trioxide aggregate (MTA)
Epigallocatechin gallate (EGCG) is a white powder that can be obtained from tea leaves. It accounts for 50-60 % of catechin content of tea polyphenols with a wide range of biological activities including antioxidant, antimicrobial, anti-inflammatory, immune regulatory, anti-tumour effects.
Sodium hypochlorite (NaOCl) is an excellent non-specific proteolytic and antimicrobial agent that provides disinfection of the dentin-pulp interface.
Mineral trioxide aggregate (MTA) is the material of choice for pulp capping in vital pulp therapy.
Bioceramic putty is a premixed, ready-to-use calcium silicate-based material which can be used as a pulp capping material.
Postoperative pain
Pain assessments will be made at 24, 48, 72 hours postoperatively using an 11-point NRS. Pain will be categorized into 4 categories as follows: 0 reading represents "no pain"; 1- 3 readings represent "mild pain"; 4- 6 readings represent "moderate pain"; 7- 10 readings represent "severe pain".
Time frame: 72 hours
Clinical success
The outcome will be considered successful in case of absence of clinical signs and symptoms indicative of pulpal or periapical pathosis (pain and tenderness to percussion). Clinical success will be evaluated at 3, 6 and 12 months.
Time frame: One year follow-up
Radiographic success
The outcome will be considered successful in case of normal periapical tissue (PAI score 1 or 2) with absence of any pathosis on recall radiographs such as root resorption. Radiographic success will be evaluated at 3, 6 and 12 months.
Time frame: One year follow-up
Dentin bridge formation
CBCT scans will be performed at 12 months follow-up to assess the formation of a dentin bridge at the interface between the pulp capping material and the radicular pulp.
Time frame: 12 months follow-up
Plan to share: Undecided
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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Cairo University