An interventional study of Remimazolam and Desflurane in Anesthesia, sponsored by Daegu Catholic University Medical Center. Recruiting at 1 site in Korea, Republic of. Open to participants aged 19 Years to 75 Years. Per ClinicalTrials.gov, last updated 2023-09-07.
Sponsored by Daegu Catholic University Medical Center · Not applicable, Interventional, and Treatment
The goal of this prospective, randomized study is to compare recovery characteristics between remimazolam anesthesia with flumazenil and desflurane anesthesia in patients undergoing closed reduction of nasal bone fracture. The main question this study aims to answer is:
Participants will receive either remimazolam or desflurane for the maintenance of general anesthesia. When the surgery ends, the anesthetic agent will be stopped. For Remimazolam group, flumazenil will be administered as an antagonist of remimazolam.
Daegu Catholic University Medical Center is the lead sponsor of 28 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
receives remimazolam for the maintenance of general anesthesia. At the end of surgery, flumazenil is administered as an antagonist of remimazolam.
Drug: Remimazolam
receives desflurane for the maintenance of general anesthesia.
Drug: Desflurane
General anesthesia was induced with 12 mg/kg/hr of intravenous remimazolam. When loss of consciousness was achieved, the infusion rate of remimazolam was reduced to 1mg/kg/hr for maintenance. At the end of surgery, 0.2 mg of flumazenil is administered.
Desflurane (1 minimum alveolar concentration (MAC) of end-tidal desflurane concentration) is used for the maintenance of general anesthesia. Induction of general anesthesia is achieved with 1-2 mg/kg of intravenous propofol bolus.
Time to follow verbal command
Time between discontinuation of anesthetic agent and response to a verbal command of moving participant's foot
Time frame: from discontinuation of anesthetic agent to response to a verbal command of moving participant's foot, up to 30 minutes
time to eye opening
Time between discontinuation of anesthetic agent and eye opening
Time frame: from discontinuation of anesthetic agent to eye opening, up to 30 minutes
time to extubation
Time between discontinuation of anesthetic agent and extubation
Time frame: form discontinuation of anesthetic agent to extubation, up to 30 minutes
Incidence of agitation during emergence period
Ricker Sedation-Agitation Scale (RSAS) \>4
Time frame: from discontinuation of anesthetic agent to 2 minutes after extubation
Mean arterial blood pressure
Mean arterial blood pressure measured in the operating room
Time frame: from 5 minutes before anesthesia induction to end of anesthesia
Started Mar 2023 (actual). Primary completion is estimated for Dec 2023, 9 months after the start.
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Studies of the drug tested here: Remimazolam
Daegu Catholic University Medical Center