An interventional study of Exercise training in VO2max, sponsored by University of the State of Santa Catarina. Completed at 1 site in Brazil. Open to male participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-02-24.
Sponsored by University of the State of Santa Catarina · Not applicable, Interventional, and Treatment
Maximal oxygen uptake (VO2max) is used to define cardiorespiratory fitness, which is important to health and sport performance in humans. Although different types of training can improve VO2max, the high intensity interval training is recognized as one of the best ways to do it. Furthermore, it has long been speculated that high intensity interval training that elicits a high time spent near VO2max could be the best way to improve VO2max. However, this theory has not been verified. Thus, the investigators performed a randomized controlled trial with crossover in healthy individuals who underwent two high intensity interval training protocols of two weeks, being a workout with longer and other with shorter time spent near VO2max.
Fifteen participants were enrolled in a randomized trial with crossover to perform two weeks of high intensity interval training with high (i.e., five times 2 minutes of work and 1 minute of recovery; T-2min:1min) or low (i.e., ten times 1 minutes of work and 30 seconds of recovery; T-1min:30seg) time spent near VO2max. The work intensity was adjusted at 85% and 87% of power output achieved at the end of incremental test for the first and second week, respectively. Before and after the T-2min:1min and T-1min:30seg, the participants performed tests to determine VO2max, lactate threshold, muscle oxidative capacity, pulmonary oxygen uptake kinetics, power output achieved at the end of incremental test, and power output related to Wingate anaerobic test. The training programs had a washout period of at least one month.
University of the State of Santa Catarina is the lead sponsor of 24 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Participants performed high intensity interval training with high time spent near VO2max three times a week for two weeks. All training sessions consisted of five times 2 minutes of work and 1 minute of passive recovery. The work intensity was adjusted at 85% and 87% of power output achieved at the end of incremental test for the first and second week, respectively. The training sessions were performed using cycle ergometer. Findings were compared to high intensity interval training with low time spent near VO2max, which followed the same exercise frequency, intensity and total duration.
Other: Exercise training
Participants performed high intensity interval training with low time spent near VO2max three times a week for two weeks. All training sessions consisted of ten times 1 minutes of work and 30 seconds of passive recovery. The work intensity was adjusted at 85% and 87% of power output achieved at the end of incremental test for the first and second week, respectively. The training sessions were performed using cycle ergometer. Findings were compared to high intensity interval training with high time spent near VO2max, which followed the same exercise frequency, intensity and total duration.
Other: Exercise training
Two weeks of high intensity interval training with high or low time spent near VO2max.
Maximal oxygen uptake
The highest 15 seconds VO2 average determined from rolling averages of 5 seconds samples measured during incremental test or confirmation test of VO2max.
Time frame: Change at Maximal oxygen uptake after two weeks
Lactate threshold
The work intensity at which blood lactate concentration increased 1 mmol.L-1 above baseline.
Time frame: Change at Lactate threshold after two weeks
Muscle oxidative capacity
Rate recovery of muscle oxygen consumption (k-mV̇O2) of the vastus lateralis, with the k-mV̇O2 indicating muscle oxidative capacity.
Time frame: Change at Muscle oxidative capacity after two weeks
Pulmonary oxygen uptake kinetics
The on-transient response for V̇O2 was fitted using a mono-exponential model, which the rate constant (k-pV̇O2) for the kinetics of V̇O2 was calculated as 1/tau (expressed in min-1).
Time frame: Change at Pulmonary oxygen uptake kinetics after two weeks
Power output achieved at the end of incremental test
Power output achieved at the end of ramp incremental test (20 W.min-1).
Time frame: Change at Power output achieved at the end of incremental test after two weeks
Wingate anaerobic test
Peak power, mean power, and minimum power were defined as the highest mechanical power output, the average power sustained throughout the 30-s period, and the power output attained before the end of the test, respectively.
Time frame: Change at Wingate anaerobic test after two weeks
Time spent near VO2max
Time spent at or above 90% or 95% of VO2max.
Time frame: First to the last day of test or training, an average of 4 weeks
Session-rating of perceived exertion
The original 10-point version.
Time frame: First to the last day of test or training, an average of 4 weeks
Perceived Recovery Status Scale
The original 10-point version from Laurent et al (2011).
Time frame: First to the last day of test or training, an average of 4 weeks
Heart rate
Measured before and during exercise and used to determine 1) the highest heart rate, 2) the time spent near highest heart rate, 3) training impulse, and 4) heart rate variability.
Time frame: First to the last day of test or training, an average of 4 weeks
Adipose tissue thickness
Adipose tissue thickness measured by a B-mode ultrasound imaging.
Time frame: Change at Adipose tissue thickness after two weeks
Body mass
Body mass measured by a digital scale.
Time frame: Change at Body mass after two weeks
Plan to share: Undecided — The data will be presented as a group (training protocol), but data from representative subjects may be presented if they add relevant information.
This study is completed, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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University of the State of Santa Catarina