CClinicalTrials.gg
CompletedNCT05725616COROTABUpdated Nov 24, 2025

Effectiveness of the Anatomical Snuff Box Approach for Coronary Angiography

An interventional study of Coronary angiography in Coronary Angiography, sponsored by GCS Ramsay Santé pour l'Enseignement et la Recherche. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-11-24.

Sponsored by GCS Ramsay Santé pour l'Enseignement et la Recherche · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
326
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The main objective of the study is to assess whether the distal radial arterial approach (snuff box or back of the hand) is not inferior to the radial arterial approach at the wrist, in the management of coronary angiography for diagnostic purposes

Read the detailed description

Coronary angiography is the reference examination for anatomical exploration coronary arteries to determine the presence or absence of a predominantly obstructive coronary disease.

Historically, the femoral approach was the most common approach used in interventional cardiology. The radial approach to the forearm presents multiple advantages over the femoral route, and it became the gold standard approach to coronary angiography and intervention percutaneous coronary. Although uncommon, vascular complications related to the radial pathway exist.

This is why a more distal radial approach, above the long tendon extensor of the thumb (at the level of the anatomical snuff box) or downstream (at the back of the hand) was suggested more than 10 years ago. This pathway is now an advantageous alternative to the radial approach of first intention, both for the patient and for the practitioner.

The two procedures are common today but few studies have been developed to compare the two approaches. Therefore, the main objective of the study is to assess whether the distal radial arterial approach (snuff box or back of the hand) is not inferior to the radial arterial approach at the wrist, in the management of coronary angiography for diagnostic purposes

02

Conditions studied

  • Coronary Angiography
03

In context

Lead sponsor

GCS Ramsay Santé pour l'Enseignement et la Recherche is the lead sponsor of 198 studies on the registry; 94 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patient, male or female, aged 18 and over
  • Patient having a diagnostic coronary angiography programmed by radial route.
  • Patient with a radial pulse at the anatomical snuff box and at the wrist noticeable

Exclusion criteria

Exclusion Criteria:

  • Patient requiring emergency coronary angiography or having an acute coronary syndrome
  • Patient with severe arteriopathy of the supra-aortic trunks
  • Patient with a history of coronary bypass surgery
  • Tall patients (>1.90m)
  • Patient allergic to xylocaine
  • Patient presenting a contraindication to the realization of a coronary angiography:

terminal IRC, pregnancy, severe sepsis....

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
326 participants (actual)

Study arms

  • Experimental
    Snuff box puncture

    Puncture of the radial artery at of the anatomical snuff box or on the back of the hand during coronary angiography

    Procedure: Coronary angiography

  • Active comparator
    Wrist puncture

    Puncture of the radial artery at the level of the base of the wrist during coronary angiography

    Procedure: Coronary angiography

Interventions

  • ProcedureCoronary angiography

    Snuff Box Approach or radial Arterial Approach at wrist for coronary angiography.

06

What researchers measure

Primary outcomes

  1. Success rate of coronary angiography without changing puncture route.

    The primary endpoint is the success rate of coronary angiography without changing puncture route.

    Time frame: 1 day

07

Study locations

1 site
  • Cardiologie Tonkin
    Villeurbanne, 69100, France
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 24, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05725616
Lead sponsor
GCS Ramsay Santé pour l'Enseignement et la Recherche
Responsible party
Sponsor
First posted
Feb 13, 2023
Start date
Jul 1, 2023
Primary completion
Jan 1, 2025
Completion
Jan 1, 2025
Last update
Nov 24, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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