An interventional study of Zymot Multi sperm separation device and Density gradient centrifugation in Infertility, Infertility Secondary and Infertility Unexplained, sponsored by University of California, San Francisco. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by University of California, San Francisco · Not applicable, Interventional, and Treatment
This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.
Study participants will be randomized to either standard sperm preparation (density gradient centrifugation) versus sperm preparation with the Zymot Multi sperm preparation device for their three month intrauterine insemination treatment course. Patients will follow standard treatment plans designed by their fertility physician and will be followed until referred for prenatal care at 8-10 weeks of pregnancy to determine pregnancy outcomes.
2,085 studies on the registry are indexed under Infertility; 357 are open to participants now.
This study's planned enrollment of 270 is above the median of 135 across 1,412 interventional studies indexed under Infertility.
Browse Infertility studies →University of California, San Francisco is the lead sponsor of 2,169 studies on the registry; 372 are open to participants now.
Of its 267 completed or terminated interventional studies of FDA-regulated products, 202 (76%) have results posted.
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Exclusion Criteria:
Patients will undergo sperm preparation by density gradient centrifugation
Other: Density gradient centrifugation
Patients will undergo sperm preparation by the Zymot sperm separation device
Device: Zymot Multi sperm separation device
Sperm preparation with Zymot Multi sperm preparation device
Sperm preparation with density gradient centrifugation
Cumulative clinical pregnancy rate
The clinical pregnancy rate by treatment group over the course of IUI treatment
Time frame: 3 treatment cycles, an average of 5 months
Plan to share: No
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