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Status unknownNCT05682703Updated Jan 12, 2023

A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Nasopharyngeal Carcinoma.

An observational study in Nasopharyngeal Carcinoma and EBV Infection, sponsored by Nanfang Hospital, Southern Medical University. Status unknown at 1 site in China. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-12.

Sponsored by Nanfang Hospital, Southern Medical University · Observational

The sponsor has not verified this record recently (last verified Dec 2022), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
2,000
Ages
18 Years to 70 Years
Sex
All
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Study summary

The transformation process of nasopharyngeal carcinoma is complex, so it is particularly important to explore the relationship between various disease states on its clinical pathway. Therefore, we carried out this study to explore the changes of plasma and urine metabolites at different stages during the occurrence and development of nasopharyngeal carcinoma.

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Conditions studied

  • Nasopharyngeal Carcinoma
  • EBV Infection
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In context

Nasopharyngeal Carcinoma

824 studies on the registry are indexed under Nasopharyngeal Carcinoma; 281 are open to participants now.

This study's planned enrollment of 2,000 is above the median of 300 across 137 observational studies indexed under Nasopharyngeal Carcinoma.

Browse Nasopharyngeal Carcinoma studies →

Lead sponsor

Nanfang Hospital, Southern Medical University is the lead sponsor of 488 studies on the registry; 213 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Subjects who met the diagnosis and criteria and were admitted to Nanfang Hospital of Southern Medical University.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • EBV virus infector: QPCR/EBV antibody, diagnosed as EBV infection patient with previous infection;
  • Nasopharyngeal carcinoma patients:Patients diagnosed as nasopharyngeal carcinoma by pathological diagnosis (2018 WHO standard);
  • Healthy people: Healthy people who have no history of nasopharynx related diseases or other known diseases that may affect blood lipid/protein metabolism and have been hospitalized in the Physical Examination Center of Southern Hospital.

Exclusion criteria

Exclusion Criteria:

  1. People who have a history of non research related liver diseases or other diseases known to affect blood metabolism (except for controlled type II diabetes);
  2. Have a history of other malignant tumors, except for fully treated basal cell carcinoma or squamous cell carcinoma and cervical carcinoma in situ;
  3. Diseases requiring long-term use of immunosuppressive drugs (including steroids), including but not limited to congenital or acquired immunodeficiency diseases or active central nervous system metastatic cancer, active infection or uncontrolled heart disease;
  4. Suffer from other uncontrolled serious diseases at the same time, such as unstable heart disease requiring treatment, diabetes with unsatisfactory control (fasting blood glucose>1.5 × Upper limit of normal value), mental illness and severe allergic history.
  5. BMI is less than 18 or more than 25. -
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Study design

Observational model
Cohort
Time perspective
Other
Enrollment
2,000 participants (estimated)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • EBV virus infector

    QPCR/EBV antibody, diagnosed as EBV infection patient

    Diagnostic Test: Proteomics technology and liquid biopsy

  • nasopharyngeal carcinoma patients

    Patients diagnosed as nasopharyngeal carcinoma by pathological diagnosis (2018 WHO standard)

    Diagnostic Test: Proteomics technology and liquid biopsy

  • Healthy people

    healthy people with no history of nasopharynx related diseases or other known diseases that may affect blood lipid/protein metabolism

    Diagnostic Test: Proteomics technology and liquid biopsy

Interventions

  • Diagnostic testProteomics technology and liquid biopsy

    using proteomics technology and liquid biopsy to investigate the changes of plasma and urine metabolites by collecting residual blood and urine from routine diagnosis and treatment or physical examination

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What researchers measure

Primary outcomes

  1. Achieve the expected number of enrolled cases

    Achieve the expected number of enrolled cases

    Time frame: 3 years

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Study locations

1 of 1 sites recruiting
  • Southern medical university
    Guangzhou, Guangdong 510515, China
    • Jian Guan, M.D. · Contact · guanjian5461@163.com · 86+13632102247
    • Jian Guan, M.D. · Principal investigator
    Recruiting
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References and documents

Publications

  • Zhou Z, Tang T, Li N, Zheng Q, Xiao T, Tian Y, Sun J, Zhang L, Wang X, Wang Y, Ye F, Chen Z, Zhang H, Zheng X, Cai Z, Liu L, Guan J. VLDL and LDL Subfractions Enhance the Risk Stratification of Individuals Who Underwent Epstein-Barr Virus-Based Screening for Nasopharyngeal Carcinoma: A Multicenter Cohort Study. Adv Sci (Weinh). 2024 Jun;11(22):e2308765. doi: 10.1002/advs.202308765. Epub 2024 Mar 23. PubMed 38520712 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 12, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05682703
Responsible party
Sponsor
First posted
Jan 12, 2023
Start date
Dec 23, 2022
Primary completion
Nov 20, 2025 (estimated)
Completion
Dec 20, 2025 (estimated)
Last update
Jan 12, 2023

Study contacts

jian guan, MD
Contact
guanjian5461@163.com
136 3210 2247
jian guan, MD
principal investigator · Nanfang Hospital, Southern Medical University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Dec 2022. You cannot join it, but the record below documents what was studied.

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