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Active, not recruitingNCT05681325Updated Dec 27, 2023

Evaluation of Antioxidant and Anti-inflammatory Effect of Matcha Tea Intake on Periodontal Health

An interventional study of green tea and matcha tea in Gingival Disease, sponsored by Hayder Raad Abdulbaqi. Active, not recruiting at 1 site in Iraq. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-12-27.

Sponsored by Hayder Raad Abdulbaqi · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Dec 2023, 2 years 9 months ago, but the record still lists the study as active, not recruiting.
  • Registered 10 months after the study started (first participant enrolled Jan 2022, registered Dec 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
All
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Study summary

Aim of the study:

This study aims to evaluate the antioxidant and beneficial effects of matcha tea daily intake on periodontal health.

Objectives:

  • To evaluate the salivary level of antioxidants (catalase, total antioxidant capacity) after matcha tea intake compared to green tea over a period of one month.
  • To evaluate the clinical periodontal parameters including bleeding on probing (BOP), probing pocket depth (PPD) and plaque index (PI) after matcha tea intake compared to green tea over a period of one month.
  • To evaluate the salivary levels of IL-1B after matcha tea intake compared to green tea over a period of one month.
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Conditions studied

  • Gingival Disease

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03

In context

Gingival Diseases

84 studies on the registry are indexed under Gingival Diseases; 25 are open to participants now.

This study's planned enrollment of 40 is below the median of 46 across 67 interventional studies indexed under Gingival Diseases.

Browse Gingival Diseases studies →

Lead sponsor

This is the only study on the registry with Hayder Raad Abdulbaqi as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

    • having at least 20 teeth,

      • underwent no medical treatment during the last 3 months before examination and sampling,
      • non-smoker,
      • no history of systemic disease,
      • gingivitis patient (having >10% bleeding sites with no PPD >3 mm).

Exclusion criteria

Exclusion Criteria:

    • wore orthodontic appliances,

      • pregnant or currently in the breast-feeding period,
      • periodontitis patient,
      • smoker,
      • has a history of systemic disease.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Investigator)
Enrollment
40 participants (estimated)

Study arms

  • Active comparator
    green tea group

    Mahmood Green Tea Sri Lanka. It will be given 2 cups / day for 30 days.

    Dietary Supplement: green tea

  • Experimental
    matcha tea group

    Jade Leaf Organic Japanese Matcha, USA. It will be given 2 cups / day for 30 days.

    Dietary Supplement: matcha tea

Interventions

  • Dietary supplementgreen tea

    It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.

  • Dietary supplementmatcha tea

    It will be given 2 cups / day for 30 days. To prepare each cup, a tea pack will be immersed into a cup of hot water.

06

What researchers measure

Primary outcomes

  1. change in salivary level of antioxidant marker

    change in level of catalase enzyme in ku/L

    Time frame: 30 Days (baseline to one moth of tea intake)

  2. change in salivary level of ant-inflammatory marker

    change in level of interleukin- one beta (IL-1B) in pg/L

    Time frame: 30 Days (baseline to one moth of tea intake)

Secondary outcomes

  1. change in percentage of bleeding on probing (BOP)

    change in BOP percentage. less percentage means less inflammation in gingival tissue

    Time frame: 30 Days (baseline to one moth of tea intake)

  2. change in plaque index (PI) scores

    change in PI scores. less scores mean less dental plaque accumulated onto teeth surfaces

    Time frame: 30 Days (baseline to one moth of tea intake)

07

Study locations

1 site
  • Universality of Baghdad, College of dentistry
    Baghdad, Iraq
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References and documents

Publications

  • Zhang Y, Kang N, Xue F, Qiao J, Duan J, Chen F, Cai Y. Evaluation of salivary biomarkers for the diagnosis of periodontitis. BMC Oral Health. 2021 May 17;21(1):266. doi: 10.1186/s12903-021-01600-5. PubMed 34001101 ↗
  • Kolackova T, Kolofikova K, Sytarova I, Snopek L, Sumczynski D, Orsavova J. Matcha Tea: Analysis of Nutritional Composition, Phenolics and Antioxidant Activity. Plant Foods Hum Nutr. 2020 Mar;75(1):48-53. doi: 10.1007/s11130-019-00777-z. PubMed 31832980 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 27, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05681325
Lead sponsor
Hayder Raad Abdulbaqi
Responsible party
Hayder Raad Abdulbaqi (professor, University of Baghdad) — Sponsor-investigator
First posted
Jan 12, 2023
Start date
Jan 25, 2022
Primary completion
Dec 30, 2023 (estimated)
Completion
Jul 12, 2024 (estimated)
Last update
Dec 27, 2023

Study contacts

HIND KAREEM, BDS
study director · University of Baghdad

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Dec 2023. You cannot join it, but the record below documents what was studied.

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