An interventional study of Neural Pressure Support (mode of mechanical ventilation) in Acute Respiratory Failure, sponsored by Karolinska Institutet. Status unknown at 1 site in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-09-19.
Sponsored by Karolinska Institutet · Not applicable, Interventional, and Treatment
In this study patients who are intubated and on ventilator for more than 24h will be ventilated at three different level of support in Pressure Support and Neural Pressure Support to study patient-ventilator synchrony and muscle unloading.
This study is an interventional randomized crossover study in intubated and mechanically ventilated patients for more than 24h. Eligible patients from whom informed consent is obtained and Pes and Edi catheter are successfully positioned are enrolled in the study. Patients will be ventilated in Pressure Support and Neural Pressure Support at three different level of assist (baseline, 50% and 150% of baseline respectively) in randomized order. Ventilator curves will be recorded and bloodgas obtained at the end of each study step, each lasting 20min.
Karolinska Institutet is the lead sponsor of 1,146 studies on the registry; 275 are open to participants now.
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-Patients intubated for more than 24 hours in the weaning phase from the ventilator.
Exclusion Criteria:
Patients will be ventilated in Pressure Support and Neural Pressure Support at 3 different levels of support in randomized order
Device: Neural Pressure Support (mode of mechanical ventilation)
Nasogastric tube will be removed and replaced by a Esophageal catheter and Electrical Diaphragm activity catheter and mechanical ventilation in mode Neural Pressure Support
Patient-ventilator asynchronies
quantification of asynchronies by the use of the Edi catheter
Time frame: 20 minutes ventilatory traces recording
respiratory muscle unloading
quantification of muscle unloading by use of Pes
Time frame: 20 minutes ventilatory traces recording
Plan to share: No
No publications or documents are linked to this record.
Started May 2022 (actual). Primary completion is estimated for Dec 2025, 43 months after the start.
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This study is status unknown, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
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