An observational study in Thrombus, Brain and Thrombosis, sponsored by Chinese PLA General Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-03.
Sponsored by Chinese PLA General Hospital · Observational
In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.
Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.
26 studies on the registry are indexed under Intracranial Thrombosis; 9 are open to participants now.
This study's planned enrollment of 100 is below the median of 256 across 14 observational studies indexed under Intracranial Thrombosis.
Browse Intracranial Thrombosis studies →Chinese PLA General Hospital is the lead sponsor of 558 studies on the registry; 202 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants who are confirmed to have extracranial and/or intracranial artery occlusion
Exclusion Criteria:
Imaging appearance of intracranial and/or extracranial arterial thrombus
Rate of Successful Recanalization
Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.
Time frame: 1-3 Years
Ischemic Stroke Occurrence
Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging
Time frame: 1-3 Years
Number of Participants with Adverse Events
hemorrhagic or ischemic stroke after recanalization treatment
Time frame: 1-3 Years
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Chinese PLA General Hospital