An observational study in Neuro-Degenerative Disease and Alzheimer Disease, sponsored by Chinese University of Hong Kong. Recruiting at 1 site in Hong Kong. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-18.
Sponsored by Chinese University of Hong Kong · Observational
Alzheimer's disease is a severe neurodegenerative disorder of the brain that is characterized by progressive loss of memory and cognitive decline. With the ageing population, AD is a major public health problem affecting nearly 35 million people worldwide with numbers projected to rise to 115.4 million by 2050. AD is the only cause of death among the top ten causes that has no prevention or cure . It is believed that novel treatment of AD needs to start early or even at the prodromal stage in order to be effective. Therefore, there is an urgent need to find accurate methods of early detection before patients with AD develop clinical dementia.
This study aims to identify biomarkers for AD in local Chinese population. this study hypothesizes blood-based proteomics, retinal imaging, ASL-MRP and tau PET can improve the accuracy and staging of AD.
This is a cohort study. It involves baseline and 6 yearly follow ups. At baseline, all participants will go through a list of cognitive assessments, blood taking, Brain MRI scan, Brain PET scan and retinal imaging.
At the first five yearly follow ups, cognitive assessment will be performed. For the sixth yearly follow up, automatic retinal image will be performed in addition to cognitive assessment.
3,675 studies on the registry are indexed under Alzheimer Disease; 869 are open to participants now.
This study's planned enrollment of 300 is above the median of 200 across 751 observational studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →Chinese University of Hong Kong is the lead sponsor of 1,419 studies on the registry; 487 are open to participants now.
Counted across the registry records on this site, refreshed daily.
AD subjects will be recruited from neurology cognitive disorder clinic of Prince of Wales Hospital. Age match normal control will be recruited from existing normal control studies.
Exclusion Criteria:
75 subject without any of the following: subjective memory complaint and cognitive impairment base on cognitive assessments
75 subjects without cognitive impairment based on cognitive cognitive assessments but with subject memory complaint
75 subjects with both subjective memory complaints and mild cognitive impairment base on cognitive assessments
75 subjects with both subjective memory complaints and moderate to severe cognitive impairment base on cognitive assessments
The score change in Hong Kong List Learn Test (HKLLT)
The Hong Kong List Learn Test would be administered to assess the cognitive status for all group of study subjects
Time frame: Baseline, 1 year, 2 year, 3 year ,4 year ,5 year and 6 year visit after baseline visit
The score change in Montreal Cognitive Assessment Hong Kong (HK-MoCA)
The Montreal Cognitive Assessment Hong Kong would be administered to assess the cognitive status for all group of study subjects
Time frame: Baseline, 1 year, 2 year, 3 year ,4 year ,5 year and 6 year visit after baseline visit
The score change Clinical Dementia Rating (CDR)
The Clinical Dementia Rating would be administered to assess the cognitive status for all group of study subjects
Time frame: Baseline, 1 year, 2 year, 3 year ,4 year ,5 year and 6 year visit after baseline visit
Amount of amyloid β with 11C-Pittsburgh compound B
Positron emission tomography imaging with 11C-Pittsburgh compound B would quantify the amount of amyloid β. Amyloid β is one of the biomarkers associate Alzheimer Disease
Time frame: Baseline
Amount of amyloid tau with T807 tracer
Positron emission tomography imaging with T807 tracer would quantify the amount of tau protein. tau protein is one of the biomarkers associate with Alzheimer Disease
Time frame: Baseline
Amount of glucose hypometabolism
Positron emission tomography imaging with 18F-FDG tracer would quantify the amount of glucose hypometabolism. glucose hypometabolism is one of the biomarkers associate with Alzheimer Disease
Time frame: Baseline
arterial spin labeling magnetic resonance perfusion (ASL-MRP)
Arterial spin labeling (ASL) perfusion is a MRI technique to quantify tissue blood flow of all group of subjects
Time frame: Baseline
Change of Automatic Retinal Imaging
There is a close anatomical correlation between both the macrovascular and the microvascular blood supply to the brain and the retina, and both vascular networks share similar vascular regulatory processes. Automatic Retinal Imaging is used to investigate microcirculations in retinal
Time frame: Baseline, 6th year follow up
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Chinese University of Hong Kong