An interventional study of Dietary regimens in Diet, Healthy, Urinary Bladder Diseases and Oncogenesis, sponsored by Roland Seiler-Blarer. Completed at 2 sites in Switzerland. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-11.
Sponsored by Roland Seiler-Blarer · Not applicable, Interventional, and Prevention
The goal of this interventional study is to test the influence of food intake with characteristics of the urinary bladder. The main questions it aims to answer are:
Biomarkers within the participants and between the diet regimes will be compared to investigate the influence of food intake on the urinary bladder.
62 studies on the registry are indexed under Urinary Bladder Diseases; 9 are open to participants now.
This study's enrollment of 13 is below the median of 79 across 42 interventional studies indexed under Urinary Bladder Diseases.
Browse Urinary Bladder Diseases studies →Roland Seiler-Blarer is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Exclusion Criteria:
For 12 weeks, healthy volunteers will follow a bladder protective diet.
Other: Dietary regimens
For 12 weeks, healthy volunteers will not follow a specific diet.
Other: Dietary regimens
Food intake will follow a recommendation according to a specific list. Protective and non-protective food intake will be performed for specific time periods with biomarker assessment after each period.
Change in molecular profile of urothelial cells
After the 12 week diet period (protective and non-protective), cells voided in urine will be sampled and examined.
Time frame: 12 weeks
Change in multiplex cytokine levels in voided urine
After the 12 week diet period (protective and non-protective), supernatant in voided urine will be used for further examination
Time frame: 12 weeks
DNA sequences in urinary microbiome
After the 12 week diet period (protective and non-protective), DNA sequencing on urinary microbiome in voided urine will be performed and compared between the different dietary regimens.
Time frame: 12 weeks
Change of BMI
After the 12 week diet period (protective and non-protective) BMI will be assessed.
Time frame: 12 weeks
Change of heart rate
After the 12 week diet period (protective and non-protective), heart rate will be assessed.
Time frame: 12 weeks
Change of blood pressure
After the 12 week diet period (protective and non-protective), systolic and diastolic blood pressure will be assessed.
Time frame: 12 weeks
Change of health status
After the 12 week diet period (protective and non-protective), health status will be assessed using the Short Form 36 (SF-36) questionaire. The possible score ranges from 0 to 100 points, with 0 points representing the greatest possible health limitation, and 100 points representing no health limitation.
Time frame: 12 weeks
Plan to share: Yes — Data from biomarker assessment and diet regimens will be provided in the general public
Supporting information: Study protocol, Analytic code
Time frame: At publication
No publications or documents are linked to this record.
Ran from Mar 2025 to primary completion in Dec 2025, 8 months.
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This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Roland Seiler-Blarer