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CompletedNCT05630144Updated Jul 16, 2025

Deprescribing for Older Adults After Hospital Discharge in Home Health Care

An interventional study of HomeMed in Polypharmacy, sponsored by University of Rochester. Completed at 1 site in United States. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2025-07-16.

Sponsored by University of Rochester · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
5
Allocation
Not applicable
Ages
65 Years and older
Sex
All
01

Study summary

The purpose of this study is to examine the feasibility of providing a medication optimization program to improve patient health outcomes during the transition from hospital to home. This is because the period after hospital discharge is critical to long-term recovery, overall quality of life, and prevention of future hospitalizations.

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Conditions studied

  • Polypharmacy
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In context

Lead sponsor

University of Rochester is the lead sponsor of 715 studies on the registry; 116 are open to participants now.

Of its 56 completed or terminated interventional studies of FDA-regulated products, 44 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Patient Inclusion Criteria:

  • 65 years of age and older
  • currently hospitalized or having been hospitalized in the previous 2 weeks
  • having a discharge disposition of home with a referral to receive HHC services from URMHC, or currently receiving HHC services from URMHC
  • taking more than 10 regular medications daily
  • having a primary care provider who is in the URMC system
  • Ability to self-consent
  • English-speaking

Patient Exclusion Criteria:

  • end-of-life prognosis in the following 6 months
  • currently receiving hospice care, end-of-life care, or palliative care
  • conditions that impact the receipt of the intervention, such as severe cognitive impairment that interferes with the subject's ability to communicate with interventionists;
  • substantial difficulties in hearing, vision, and verbal expression that disable the participant from communicating effectively while receiving the HomeMed intervention
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
5 participants (actual)

Study arms

  • Experimental
    All Participants

    Behavioral: HomeMed

Interventions

  • BehavioralHomeMed

    The HomeMed intervention is a multidisciplinary deprescribing intervention including home visits and team-based telehealth communication (optional). The components included in the HomeMed intervention include home medication review, medication education and provision of tools to assist the patients with medication administration, assessment of deprescribing targets by a trained geriatric clinical pharmacist, communication with the patient's treating primary care provider about deprescribing recommendation, deprescribing implementation (optional), and deprescribing monitoring (optional). Depending on the patient's treating primary care provider's decision on deprescribing and monitoring, the number of home visits ranges from a minimum of three to more with the entire duration of the intervention ranging from approximately 1 to 3 months.

06

What researchers measure

Primary outcomes

  1. mean time spent on intervention

    Time frame: 3 months

  2. number of participants who complete a post intervention survey about feasibility

    Time frame: 3 months

  3. Percentage of participants undergoing deprescribing

    Time frame: 3 months

  4. Percentage of intervention adherence indicators checked

    Time frame: 3 months

  5. Percentage of patients who improve in ability to do things that are important before and after intervention

    Time frame: 3 months

  6. Total number of medications used per participant

    Time frame: 3 months

  7. Percentage of patients who report a reduction in medication burden

    Medication burden will be reported by phone or survey.

    Time frame: 3 months

  8. Percentage of participants who report a reduction in medication side effect

    Side effects will be collected by phone.

    Time frame: 3 months

07

Study locations

1 site
  • University of Rochester Medical Center
    Rochester, New York 14642, United States
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 16, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05630144
Lead sponsor
University of Rochester
Collaborators
National Institute on Aging (NIA)
Responsible party
Thomas Caprio (Professor - Department of Medicine, Geriatrics/Aging (SMD), University of Rochester) — Principal investigator
First posted
Nov 29, 2022
Start date
Mar 29, 2023
Primary completion
May 30, 2025
Completion
May 30, 2025
Last update
Jul 16, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.

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