A Study in People With Advanced Cancer to Test How BI 907828 is Processed in the Body

• Signed and dated written informed consent in accordance with International Conference on Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial.

• Male patients, age 18-70 years; or women of non-childbearing potential* aged ≥ 18 years and ≤ 70 years at the time of signature of the ICF.

  *Non-childbearing potential is defined as permanently sterile or post-menopausal. Permanent sterilization methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. Tubal ligation is NOT a method of permanent sterilization. Postmenopausal defined as at least 1 year of spontaneous amenorrhea (in questionable cases a blood sample with levels of FSH above 40 U/L or 40 IU/L and estradiol below 30 ng/L or 110.13 pmol/L is confirmatory) without an alternative medical cause.

• Histologically or cytologically confirmed diagnosis of an advanced, unresectable and/or metastatic solid tumor.
• Patients with measurable or non-measurable disease. Non-evaluable disease is allowed.
• Patient who has failed or rejected conventional treatment or for whom no therapy of proven efficacy exists or who is not eligible for established treatment options. Patient should have exhausted available treatment options known to prolong survival for their disease.
• BMI of 18.5 to 29.9 kilogram per square meter (kg/m2) at Screening.
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.
• All toxicities related to previous anti-cancer therapies have resolved ≤ CTCAE Grade 1 prior to trial treatment administration (except for alopecia and peripheral neuropathy which must be ≤ Common Terminology Criteria for Adverse Events (CTCAE) Grade 2 and). Note: Patients with chronic grade 2 toxicities that are asymptomatic or adequately managed with stable medication may be eligible with approval from the Sponsor.
• Further inclusion criteria apply.

Exclusion Criteria:

• Patients with known TP53 mutant tumours (Note: testing is not mandatory for inclusion).
• Second malignancy currently requiring active therapy (except for hormonal /antihormonal treatment e.g. in prostate or breast cancer).
• Received chemo-, immuno-, or molecular-targeted cancer-therapy or investigational drug within the past 30 days or within 5 half-life periods (as far as known for investigational therapies) prior to the initiation of trial treatment or planning to receive any of these therapies concomitantly with this trial. This restriction does not apply to steroids, bisphosphonates, and hormonal/antihormonal treatment (e.g. in prostate or breast cancer).
• Patients who have received radiotherapy within 4 weeks prior to trial entry. Note: Patients receiving limited palliative radiation to non-gastrointestinal areas within 4 weeks prior to trial entry may still be eligibility upon discussion with and confirmation from the Sponsor.
• No ¹⁴C related study medication containing over 0.1 Megabecquerel (MBq) radiation in the last 12 months prior to dosing in the current study.
• Clinical evidence of active brain metastasis or leptomeningeal disease in the past 6 months prior to screening.
• Irregular defecation pattern (less than once per 2 days) or urinary incontinence (applicable for Cohort 1 (ADME) patients only).
• Patient is unwilling to undergo intensive blood sampling or has veins unsuitable for blood sampling or infusion.
• Further exclusion criteria apply.