An observational study in Infertility, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to female participants aged 18 Years to 43 Years. Per ClinicalTrials.gov, last updated 2025-12-26.
Sponsored by University Hospital, Lille · Observational
The ENDALGOFIV study of pain assessment during the IVF pathway at Lille University Hospital, conducted from November 2018 to July 2020, showed that endometriosis patients have intense pain, particularly of a neuropathic nature, even before starting their IVF pathway compared to patients without endometriosis, but without an increase in pain scores during the IVF pathway. As a result of this study, a new pain management protocol for all patients undergoing IVF have been implemented in our MPA center. The study will be evaluated the impact of this new management.
Main objective To evaluate the effect of the change in pain management protocol in all patients (endometriotic or not) undergoing IVF treatment during the study period by comparing them to the data of the ENDALGOFIV 1 study.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 206 is close to the median of 200 across 714 observational studies indexed under Infertility.
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All patients who start an IVF cycle in the medically assisted procreation department of the Jeanne de Flandre Hospital (CHRU Lille)
Exclusion Criteria:
Survey will be at different time of the IVF protocol (at the first medical appointment in the medically assisted department, after stimulation, after oocytes retrieval, after embryo transfer, one month after the IVF protocol)
Questionnaire douleur Saint Antoine (QDSA)
QDSA for emotional and sensory dimension of pain. It's a word list to describe a pain, patient must specify the type of pain that she usually feels for 8 days by putting a cross for the correct answer (0 to 4: absent, weak, moderate, strong, extremely strong). Scored from 0 to 64
Time frame: After puncture, before discharge from hospital (assessed up to 24 hours)
Questionnaire douleur Saint Antoine (QDSA)
compare the evolution of pain during study between the 2 groups endometriosis - non endometriosis
Time frame: At baseline and during procedure ( an average up to 6 weeks)
EN = numerical scale of pain
from 0 to 10 (0 is "no pain" and 10 is "maximum pain imaginable") compare the evolution of pain during study between the 2 groups endometriosis - non endometriosis
Time frame: At baseline and during procedure ( an average up to 6 weeks)
DN4
emotional and sensory dimension of pain, neuropathic pain survey in four questions - score on 7 compare the evolution of pain during study between the 2 groups endometriosis - non endometriosis
Time frame: At baseline and during procedure ( an average up to 6 weeks)
HAD,anxiety and depression
2 scores on 21 - "circle the number that best fits your condition" Compare the evolution of pain during study according to the 2 periods (ENDALGOFIV 1 patients and patients who benefited from the new management protocol)
Time frame: At baseline and during procedure ( an average up to 6 weeks)
EQ-5D quality of life
overall score on a numeric scale "check the box that best describes your health today", 5 themes (mobility, autonomy of the person, common activities, pain / discomfort, anxiety / depression) Compare the evolution of pain during study according to the 2 periods (ENDALGOFIV 1 patients and patients who benefited from the new management protocol)
Time frame: At baseline and during procedure ( an average up to 6 weeks)
pain catastrophism scale (PCS)
score between 0 to 52. Compare the evolution of pain during study according to the 2 periods (ENDALGOFIV 1 patients and patients who benefited from the new management protocol)
Time frame: At baseline and during procedure ( an average up to 6 weeks)
willingness to go the pain consultation: yes or no answer
measure the impact of the pain on the pregnancy project and on the analgesic management after stimulation between the 2 endometriosis - non-endometriosis groups
Time frame: during the stimulation period (an average 10 days)
willingness to take a antalgic medication during the stimulation: yes or no answer
measure the impact of the pain on the pregnancy project and on the analgesic management after stimulation between the 2 endometriosis - non-endometriosis groups
Time frame: during the stimulation period (an average 10 days)
willingness to take a antalgic medication during the punction: yes or no answer
measure the impact of the pain on the pregnancy project and on the analgesic management after stimulation between the 2 endometriosis - non-endometriosis groups
Time frame: during the stimulation period (an average 10 days)
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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University Hospital, Lille