ClinicalTrials.gg
CompletedNCT05577806Updated Oct 13, 2022

DYG Versus Cetrorelix in Oocyte Donation

An observational study in Infertility, Female and Fertility Disorders, sponsored by Clinica de la Mujer Medicina Reproductiva, Chile. Completed. Open to female participants aged 21 Years to 30 Years. Per ClinicalTrials.gov, last updated 2022-10-13.

Sponsored by Clinica de la Mujer Medicina Reproductiva, Chile · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
202
Ages
21 Years to 30 Years
Sex
Female
01

Study summary

Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter >18mm.

02

Conditions studied

  • Infertility, Female
  • Fertility Disorders

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Keywords

  • Gonadotrophin-releasing hormone (GnRH) analogues
  • Ovarian stimulation
  • Oocyte donation
  • Progestin-primed ovarian stimulation
  • Dydrogesterone
03

In context

Infertility, Female

552 studies on the registry are indexed under Infertility, Female; 137 are open to participants now.

This study's planned enrollment of 202 is above the median of 161 across 162 observational studies indexed under Infertility, Female.

Browse Infertility, Female studies →

Lead sponsor

Clinica de la Mujer Medicina Reproductiva, Chile is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years to 30 Years
Sexes eligible
Female
Sampling method
Non-probability sample

Study population

Oocyte donors undergoing controlled ovarian stimulation

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a (BMI) between 18 and 28 kg/m2 without any relevant personal or family history

Exclusion criteria

Exclusion Criteria:

  • AMH less than 3 ng/dL
  • A positive screening for sexually transmitted diseases
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

05

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
202 participants (estimated)
Patient registry
No

Groups and cohorts

  • DYG

    oocyte donors undergoing controlled ovarian stimulation in a progestin-primed ovarian stimulation protocol with DYG protocol (20mg/day)

    Drug: Dydrogesterone

  • Cetrorelix

    oocyte donors undergoing controlled ovarian stimulation in a GnRH antagonist protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm

Interventions

06

What researchers measure

Primary outcomes

  1. Live Birth Rate per transfer

    Time frame: 40 weeks after ET

  2. Clinical pregnancy per transfer

    Time frame: 12 weeks after ET

  3. Miscarriage rate

    Time frame: 12 weeks after ET

Secondary outcomes

  1. Number of oocytes retrieved

    Time frame: at time of oocyte retrieval

  2. Number of mature oocytes

    Time frame: 1 day after IVF

  3. Number of fertilized oocytes

    Time frame: 1 day after IVF

  4. Number of blastocists

    Time frame: 5-6 days after OPU

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2017 to primary completion in Dec 2021, 59 months.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 10, 2022
First posted
Oct 13, 2022
StartActual
Jan 1, 2017
Primary completionActual
Dec 31, 2021
CompletionActual
Dec 31, 2021
Last update
Oct 13, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Oct 13, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05577806
Lead sponsor
Clinica de la Mujer Medicina Reproductiva, Chile
Responsible party
Jose Antonio Moreno (MD, PhD, Clinica de la Mujer Medicina Reproductiva, Chile) — Principal investigator
First posted
Oct 13, 2022
Start date
Jan 1, 2017
Primary completion
Dec 31, 2021
Completion
Dec 31, 2021
Last update
Oct 13, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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