An observational study in Generalized Anxiety Disorder and Oxygenation Sensitive CMR, sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre. Recruiting at 1 site in Canada. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-24.
Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre · Observational
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers. The MRI measurements used will be Oxygenation-Sensitive Cardiac MRI (OS-CMR), a recent type of MRI which is safe, fast, and non-invasive.
The investigators will prospectively analyze OS-CMR data from patients with a generalized anxiety disorder from one site. The investigators will observe how an anxiety disorder affects the OS-CMR data. In a follow-up MRI scan, the investigators will look at the OS-CMR of a subgroup who have anxiety disorder and are also undertaking cognitive behavioural therapy to asses how and if this therapy affects the OS-CMR data.
4,868 studies on the registry are indexed under Anxiety Disorders; 1,388 are open to participants now.
This study's planned enrollment of 84 is below the median of 150 across 606 observational studies indexed under Anxiety Disorders.
Browse Anxiety Disorders studies →McGill University Health Centre/Research Institute of the McGill University Health Centre is the lead sponsor of 414 studies on the registry; 106 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study will recruit patient participants who are identified as having Generalized Anxiety Disorder (GAD), as well as age-similar healthy volunteer participants.
Patient population:
Age 18-55,
Healthy Volunteers:
Exclusion Criteria:
Participants diagnosed with Generalized Anxiety Disorder
Diagnostic Test: Cardiac MRI
Participants with no pre-existing conditions and who are on no medications.
Diagnostic Test: Cardiac MRI
The 4-minute breathing maneuver comprised of 2 minutes of normal breathing and 1-min hyperventilation (rate of 30 breaths per minute) followed by a maximal breath-hold. This technique is used in Oxygenation Sensitive CMR, a type of MRI, and will induce a vasoactive response visible in cardiac and cerebral MRI images
Also known as: Breathing Maneuvers
Change in Signal Intensity
Change in signal intensity between the baseline signal intensity and the signal intensity at 30 seconds of breath hold
Time frame: Baseline
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McGill University Health Centre/Research Institute of the McGill University Health Centre