An interventional study of High-Fiber Diet (HFD) and Prebiotic Food-Enriched Diet (PreFED) in Influenza, sponsored by M.D. Anderson Cancer Center. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-14.
Sponsored by M.D. Anderson Cancer Center · Not applicable, Interventional, and Supportive care
To learn if diet can enhance the microbes (such as bacteria and viruses) found in your gut and improve the body's immune response to the influenza (flu) vaccine.
Primary Objectives:
--To determine the feasibility of two dietary intervention strategies focused on fiber-rich and prebiotic foods prior to seasonal influenza vaccination. Feasibility is defined as ≥ 80% of subjects being compliant with the intervention.
Secondary Objectives:
Exploratory Objectives:
2,214 studies on the registry are indexed under Influenza, Human; 163 are open to participants now.
This study's enrollment of 31 is below the median of 238 across 1,853 interventional studies indexed under Influenza, Human.
Browse Influenza, Human studies →M.D. Anderson Cancer Center is the lead sponsor of 2,999 studies on the registry; 581 are open to participants now.
Of its 599 completed or terminated interventional studies of FDA-regulated products, 402 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants are expected to eat only the study meals and snacks provided
Dietary Supplement: High-Fiber Diet (HFD)
Participants are expected to incorporate study snacks and meal components provided into your usual diet.
Dietary Supplement: Prebiotic Food-Enriched Diet (PreFED)
Participants are assigned to the high fiber diet, all meals and snacks will be provided to participants during the study. This diet includes fruits, vegetables and whole grains, a maximum of 18 oz. cooked red meat (including beef, pork, and lamb) per week, and little or no processed meats or added sugars.
Participants are assigned to the prebiotic food enriched diet, participants will receive 2 prepared snacks and 1 meal component (a key prebiotic ingredient to incorporate into meals and simple recipes) each day. Participants will also receive a handout that includes key prebiotic foods to incorporate into your own diet.
Feasibility of dietary intervention prior to seasonal influenza vaccination defined as ≥ 80% of subjects being compliant with the intervention in the cohort
Time frame: through study completion an average of 1 year.
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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M.D. Anderson Cancer Center