An interventional study of Platelet Rich Plasma Intrauterine infusion and Normal saline Intrauterine infusion in Infertility of Uterine Origin, sponsored by Reproductive Medicine Associates of New Jersey. Recruiting at 1 site in United States. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-06-03.
Sponsored by Reproductive Medicine Associates of New Jersey · Not applicable, Interventional, and Treatment
To determine the effectiveness of an intrauterine PRP infusion on endometrial thickness and in vitro fertilization (IVF) outcomes in a population of infertile women with a history of unresponsive thin endometrium.
Patients with a history of thin endometrium will be randomized to either an intrauterine infusion of PRP vs. a placebo infusion of normal saline. This is a double-blind, placebo controlled prospective RCT. Patients will then proceed with a frozen embryo transfer of a single euploid embryo per routine.
2,085 studies on the registry are indexed under Infertility; 357 are open to participants now.
This study's planned enrollment of 62 is below the median of 135 across 1,412 interventional studies indexed under Infertility.
Browse Infertility studies →Reproductive Medicine Associates of New Jersey is the lead sponsor of 55 studies on the registry; 8 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
an intrauterine infusion of platelet rich plasma (PRP) will be administered to this group
Other: Platelet Rich Plasma Intrauterine infusion
an intrauterine infusion of normal saline will be administered to this group
Other: Normal saline Intrauterine infusion
an intrauterine infusion of platelet rich plasma (PRP) will be administered to this group of participants
an intrauterine infusion of normal saline will be administered to this group of participants
Endometrial Thickness during frozen embryo transfer
peak endometrial thickness prior to initiation of progesterone
Time frame: during the proliferative phase of the frozen embryo transfer cycle
Sustained implantation rate
presence of fetal heart beat upon discharge from care
Time frame: approximately 9 weeks gestational age
Plan to share: No
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Reproductive Medicine Associates of New Jersey