CClinicalTrials.gg
CompletedNCT05536492Updated Oct 11, 2023

Sticky Bone Compared to A-PRF(Platlet Rich Fibrin) Effect on Alveolar Ridge Preservation

An interventional study of A-PRF and ALLOGRAFT in A-PRF and ALLOGRAFT, sponsored by Arab American University (Palestine). Completed at 1 site in Palestinian Territory, occupied. Per ClinicalTrials.gov, last updated 2023-10-11.

Sponsored by Arab American University (Palestine) · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
17
Allocation
Randomized
Sex
All
01

Study summary

In this research investigators are going to detect the effect of using different type of materials(sticky bone\platlet rich fibrin ) compared to normal healing on the dimensional changes of alveolar crest after single rooted tooth extraction by using CBCT (cone-beam computed tomography) at time of extraction and after 16-24 weeks

Read the detailed description

Patients who are treated and referred for having extractions in the upper and lower arch for single rooted teeth will have CBCT for each patient at time of extraction (T0) and after 3 months (T1) , by using the cross sectional of the CBCT investigators will measure the difference from the middle of the socket to buccal and palatal\lingual walls at 3 different points below the crest 1mm, 3mm , 5mm .

  • the thickness of the buccal bone at baseline (T0) at 1, 3 and 5 mm below the crest
  • the horizontal ridge width at crest- 1 mm (HW- 1 mm), crest- 3 mm (HW- 3 mm) and crest- 5 mm (HW- 5 mm) at the buccal/palatal side, in millimetres and later transformed to percentages
  • the vertical resorption on both buccal and palatal side, in millimetres
  • the socket fill defined as the highest point of viewable mineralized bone at the middle of the socket; absolute values (in mm) and percentages were calculated by comparing the initial depth of the socket and the depth after three months of healing preparation of the materials to be augmented : autologous fibrin glue mixed with bone graft(sticky bone) would be prepared by using green tubes by choukroun company centrifuged at 1300 rpm for 14 minutes (using DUE centrifuge) then mixed with 0.5 cc FDBA and the exudate of the compressed A-PRF then applied to the extraction site A-PRF PLUGS will be prepared using red tubes using venous blood centrifuged at 1300 rpm for 14 min , then the compressed using special tray and applied in the extraction sockets
02

Conditions studied

  • A-PRF
  • ALLOGRAFT
03

In context

Lead sponsor

Arab American University (Palestine) is the lead sponsor of 12 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • presence of the buccal and palatal/lingual bony walls evaluated clinically by measuring the thickness of the alveolar ridge and radiologically by a CBCT , and residual periodontal attachment of at least 6 mm of single rooted tooth

Exclusion criteria

Exclusion Criteria:

  • complicated tooth extraction, and any medical problem that could interfere with the mucosal and bony healing processes or contraindicating an implant placement, such as anticoagulation, antiaggregatory medication, radiotherapy, bisphosphonate therapy, diabetes, endocarditis risk factors, immunosuppression, and renal or hepatic failure
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
17 participants (actual)

Study arms

  • No intervention
    G1-Control group

    normal socket healing after extraction without intervention

  • Experimental
    G2

    SOCKET AUGMENTATION WITH A-PRF ALONE

    Procedure: A-PRF

  • Experimental
    G3

    SOCKET AUGMENTATION WITH A-PRF + ALLOGRAFT

    Procedure: A-PRF · Procedure: ALLOGRAFT

Interventions

  • ProcedureA-PRF

    EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF

  • ProcedureALLOGRAFT

    EXTRACTION FOR SINGLE rooted tooth followed by augmentation with PRF + ALLOGRAFT

06

What researchers measure

Primary outcomes

  1. RIDGE DIMENSIONS

    USING CBCT

    Time frame: 4 Months

  2. BONE DENSITY

    USING CBCT

    Time frame: 4 MONTHS

07

Study locations

1 site
  • ArabAmericanU
    Ramallah, West Bank, Palestinian Territory, occupied
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 11, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05536492
Lead sponsor
Arab American University (Palestine)
Responsible party
Ahmad Nassar (dentist and clinical Msc student, Arab American University (Palestine)) — Principal investigator
First posted
Sep 13, 2022
Start date
Sep 7, 2022
Primary completion
Sep 30, 2023
Completion
Oct 1, 2023
Last update
Oct 11, 2023

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2023. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion