An interventional study of Functional Magnetic Resonance Imaging (pCASL-MRI) and Intragastric Balloon in Healthy, sponsored by Mayo Clinic. Active, not recruiting at 1 site in United States. Open to participants aged 21 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-18.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Supportive care
The purpose of this study is to investigate how gut hormones and brain areas respond differently to gastric distention, tasteless calories, or palatable food and how this alters appetite.
Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Functional Magnetic Resonance Imaging (pCASL-MRI) after Caloric and Volumetric stimulus in lean patients will be performed on all patients in the study
Other: Functional Magnetic Resonance Imaging (pCASL-MRI) · Other: Intragastric Balloon · Other: Elemental Meal · Other: Hedonic Meal
MRI's will be performed at multiple points on each visit day.
Intragastric Balloon will be placed during Visit 2 study day and inflated to maximum tolerated volume. Patient will then be scanned in the MRI.
Also known as: IGB
Patient will ingest the tasteless elemental meal until their maximum level of fullness. Once full, the patient will be scanned in the MRI.
Patient will ingest meal of their choice from a local food delivery service and eat until they reach their maximum level of fullness. Once full, the patient will be scanned in the MRI
Difference in Cerebral Blood Flow related to hypothalamus
The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the hypothalamic area.
Time frame: 1 month
Cerebral Bloodflow related in multiple brain areas
The mean difference in cerebral blood flow (CBF) at fullness (satiation) and return to hunger (satiety) to the other brain areas related to food intake regulation.
Time frame: 1 month
Cerebral Blood Flow between three stimuli
The mean difference in cerebral blood flow (CBF) between the 3 different stimuli.
Time frame: 1 month
Hormone level
Differences in hormones levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin) at each of the stages (I.e., baseline, fullness, maximal fullness) after the three different stimulations. These hormones will be compared before and after the same stimulation days. The hormone measurements on stimulation days will also be compared to each other.
Time frame: 1 month
comparison of calories
Correlation the caloric consumption to fullness, maximal fullness with degree of cerebral blood flow(CBF) change on PASL MRI.
Time frame: 1 month
calorie corellation to hormones
Correlation the caloric consumption to fullness, maximal fullness with changes in the hormonal levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin).
Time frame: 1 month
hormone level comparison
Differences in the hormonal levels (ghrelin, GLP-1, CCK, PYY, leptin, insulin, GIP, amylin) between fullness and hunger after the three different stimulations. These hormones will be compared before and after the same stimulation days. The hormone measurements on stimulation days will also be compared to each other.
Time frame: 1 month
Time differences in stimuli
Differences in time to next meal after maximal fullness after the three different stimulations.
Time frame: 1 month
Caloric consumption differences in stimuli
Differences in the caloric consumption after maximal fullness after the three different stimulations.
Time frame: 1 month
FitBit measured Physical Activity
Measurement of daily physical activity during free-living conditions measured through the use of FitBit tracker over the duration of the study.
Time frame: 1 month
Plan to share: No
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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