An interventional study of transcranial direct current stimulation and naming training in Alzheimer Disease, sponsored by Baycrest. Recruiting at 1 site in Canada. Open to participants aged 50 Years to 90 Years. Per ClinicalTrials.gov, last updated 2024-08-13.
Sponsored by Baycrest · Not applicable, Interventional, and Treatment
There is currently little symptomatic therapy for Alzheimer's Disease (AD) and nothing effective for individuals with Frontotemporal dementia (FTD). However, neuromodulation with transcranial direct current stimulation (tDCS) has the potential to be a clinically effective therapy for both AD and FTD. The challenge now is to specify the parameters and conditions under which tDCS is most effective to transition from the laboratory to clinical medicine. tDCS studies typically report significant group effects despite the variability demonstrated among participants, with some showing clear, meaningful improvement, while others only show statistical improvement or none at all. These variable results may be related to the conventional stimulation intensity level of 2mA. The investigators predict that administering tDCS at 4.0 mA, a more significant number of participants would show a meaningful response, and those who improve at 2mA may improve even more from 4.0mA due to having a larger electric field produced. The investigators aim to test this hypothesis in people with Alzheimer's Disease.
3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.
This study's planned enrollment of 42 is below the median of 70 across 2,808 interventional studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →Baycrest is the lead sponsor of 33 studies on the registry; 7 are open to participants now.
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Exclusion Criteria:
Device: transcranial direct current stimulation and naming training
Device: transcranial direct current stimulation and naming training
Device: transcranial direct current stimulation and naming training
Participants will receive mild stimulation or no stimulation along with naming training
Naming Training
The primary outcome measure will be change on the naming lists administered, both a trained version and an untrained version. This change will be measured in terms of the number of images correctly named post-training compared to baseline
Time frame: 3 months
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Plan to share: Undecided
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