An interventional study of Lidocaine and Normal saline (NS) in Organ Protection, sponsored by General Hospital of Ningxia Medical University. Status unknown. Open to participants aged 65 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-08-16.
Sponsored by General Hospital of Ningxia Medical University · Not applicable, Interventional, and Prevention
The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.
Postoperative cognitive dysfunction (POCD) is a major complication following surgeries and anesthesia, especially in elderly individuals. Lidocaine, an inexpensive, widely available, and relatively safe compound, is a local anesthetic that readily crosses the blood-brain barrier. Intravenous lidocaine can reduce the incidence of POCD. However, the mechanism is still unclear.
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are regulated by miRNA-206 and miRNA-98 respectively, play a key role in learning, memory, and cognition. Previous studies have shown that the levels of BDNF and NGF can be improved by lidocaine.
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD, and the levels of BDNF, NGF, miRNA-206 and miRNA-98 in elderly patients undergoing abdominal surgery under general anesthesia.
General Hospital of Ningxia Medical University is the lead sponsor of 102 studies on the registry; 39 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the first hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.
Drug: Lidocaine
Normal saline administered as a bolus and an infusion with identical volume and rate changes as the treatment group.
Other: Normal saline (NS)
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the frst hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery
Patients are received equal volumes of saline intravenously until the end of the surgery
Changes from Baseline BDNF at 1, 3 days after surgery
Venous blood samples were sampled before anaesthesia induction and 1, 3 days after surgery for the BDNF by using Enzyme-linked immunosorbent assay.
Time frame: at preoperation,1 and 3 days postoperation
Changes from Baseline NGF at 1, 3 days after surgery
Venous blood samples were sampled before anaesthesia induction and 1, 3 days after surgery for the NGF by using Enzyme-linked immunosorbent assay.
Time frame: at preoperation,1 and 3 days postoperation
Changes from Baseline miRNA-206 at 1, 3 days after surgery
Venous blood samples were sampled before anaesthesia induction and 1, 3 days after surgery for the miRNA-206 by using PCR.
Time frame: at preoperation,1 and 3 days postoperation
Changes from Baseline miRNA-98 at 1, 3 days after surgery
Venous blood samples were sampled before anaesthesia induction and 1, 3 days after surgery for the miRNA-98 by using PCR.
Time frame: at preoperation,1 and 3 days postoperation
Changes from Baseline mini-mental state examination (MMSE) at 1, 3 days after surgery
MMSE was performed
Time frame: at preoperation,1 and 3 days postoperation
Postoperative cognitive dysfunction (POCD)
the incidence of POCD
Time frame: at preoperation,1 and 3 days postoperation
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
General Hospital of Ningxia Medical University