An observational study in Rejection of Kidney Allograft, sponsored by University of Minnesota. Active, not recruiting at 1 site in United States. Open to participants aged Up to 21 Years. Per ClinicalTrials.gov, last updated 2025-12-17.
Sponsored by University of Minnesota · Observational
The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody mediated rejection. The study hypothesizes that blood gene expression profile and donor-derived cell-free DNA biomarkers (omnigraf) can be used to predict acute rejection and monitor its response to treatment.
University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.
Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.
Counted across the registry records on this site, refreshed daily.
Pediatric kidney transplant recipients, ages \< 21 years, scheduled to undergo a for-cause kidney biopsy to rule out graft rejection
Exclusion Criteria:
Includes blood draws and data collection only
Biopsy-proven acute rejection
Yes or No assessment
Time frame: 7 days from baseline
Clinical resolution of rejection
Yes or No assessment; defined as improvement in serum creatinine to a value that is within 25% of baseline serum creatinine
Time frame: 8 weeks from baseline
This study is active, not recruiting, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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University of Minnesota