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RecruitingNCT05437198EXHALBIOUpdated Jun 16, 2026

Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD

An observational study in Chronic Obstructive Pulmonary Disease, sponsored by Centre Hospitalier Intercommunal Creteil. Recruiting at 1 site in France. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-06-16.

Sponsored by Centre Hospitalier Intercommunal Creteil · Observational

From the registry’s dates

  • Started Mar 2024; still recruiting 2 years 6 months later.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
240
Ages
18 Years to 70 Years
Sex
All
01

Study summary

COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.

a second collection for the year +1 will be made, at the same time (between October and March).

Read the detailed description

The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies.

After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician.

A collection of the exhalation will also be carried out by the clinical study technician.

Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status

02

Conditions studied

  • Chronic Obstructive Pulmonary Disease
03

In context

Pulmonary Disease, Chronic Obstructive

4,131 studies on the registry are indexed under Pulmonary Disease, Chronic Obstructive; 697 are open to participants now.

This study's planned enrollment of 240 is above the median of 180 across 1,066 observational studies indexed under Pulmonary Disease, Chronic Obstructive.

Browse Pulmonary Disease, Chronic Obstructive studies →

Lead sponsor

Centre Hospitalier Intercommunal Creteil is the lead sponsor of 131 studies on the registry; 36 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Subjects with chronic obstructive pulmonary disease (COPD) and no-COPD control subjects

Inclusion criteria

For COPD:

  • Patients with chronic obstructive pulmonary disease
  • Age: over 18

For non-COPD

  • Absence of chronic obstructive pulmonary disease
  • Age: between 18 and 30 years old and between 45 and 70 years old

Exclusion criteria

Exclusion Criteria:

  • Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants)
  • Person under guardianship or curatorship
  • Pregnant or breastfeeding women
  • Person unable to express his/her opposition, person deprived of liberty
  • Existence of a chronic infectious pulmonary pathology such as (dilation of the bronchi, cystic fibrosis)
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
240 participants (estimated)
Patient registry
No

Groups and cohorts

  • Chronic Obstructive Pulmonary Disease (COPD)

    Patients with chronic obstructive pulmonary disease will be recruited from the pulmonology or occupational pathology department. They are either active smokers or ex-smokers. They are over 18 years old

    Other: collection of human exhalation

  • NO-Chronic Obstructive Pulmonary Disease

    The no-COPD are controls followed in chi créteil for another pathology. They are between 18 and 30 years old and 45 and 70 years old. They are either: * Ex-smoker * Active smoker * Non-smoker

    Other: collection of human exhalation

Interventions

  • Othercollection of human exhalation

    the collection of the exhalation will be carried out with a non-invasive device manufactured by a Chinese company. The collection of exhalation consists of the subject inhaling through the nose and exhaling gently through the mouth through a plastic straw for a time set at 5 min in the device

06

What researchers measure

Primary outcomes

  1. Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects

    number and bacterial species

    Time frame: Baseline

Secondary outcomes

  1. Number and dominant bacterial species in human exhalations according to smoking status

    number and bacterial species

    Time frame: Baseline

  2. Number and dominant bacterial species in human exhalations according to age

    number and bacterial species

    Time frame: Baseline

  3. Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season

    number and bacterial species

    Time frame: 1 year

07

Study locations

1 of 1 sites recruiting
  • Centre Hospitalier Intercommunal de Créteil
    Créteil, 94010, France
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 16, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05437198
Lead sponsor
Centre Hospitalier Intercommunal Creteil
Responsible party
Sponsor
First posted
Jun 29, 2022
Start date
Mar 26, 2024
Primary completion
Mar 2028 (estimated)
Completion
Mar 2029 (estimated)
Last update
Jun 16, 2026

Study contacts

Jean-Claude PAIRON, PhD
Contact
jc.pairon@chicreteil.fr
01 45 02 20 93
Camille JUNG, PhD
Contact
camille.jung@chicreteil.fr
0145175000
Jean Claude PAIRON, PhD
principal investigator · CHI créteil

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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