An interventional study of Intermittent theta-burst stimulation (iTBS) in Healthy, sponsored by The Hong Kong Polytechnic University. Completed at 1 site in Hong Kong. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-09-15.
Sponsored by The Hong Kong Polytechnic University · Not applicable, Interventional, and Basic science
Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows the investigators to observe the prefrontal hemodynamic response during stimulation.
The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.
Please refer to the full proposal
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Exclusion Criteria:
Participants will receive 50% rMT iTBS over left DLPFC in this arm. The prefrontal hemodynamic response will be observed simultaneously before, during, and after iTBS using fNIRS.
Device: Intermittent theta-burst stimulation (iTBS)
Participants will receive 70% rMT iTBS over left DLPFC in this arm. The prefrontal hemodynamic response will be observed simultaneously before, during, and after iTBS using fNIRS.
Device: Intermittent theta-burst stimulation (iTBS)
Participants will receive 90% rMT iTBS over left DLPFC in this arm. The prefrontal hemodynamic response will be observed simultaneously before, during, and after iTBS using fNIRS.
Device: Intermittent theta-burst stimulation (iTBS)
The iTBS will be applied over lDLPFC with three different intensities. The investigators put the NIRS probe under the TMS coil to detect the hemodynamic signal simultaneously, and the applied rMT was adjusted based on Stokes et al., 2007. The equation is AdjMT% = MT + 2.8 \* (Dsitex - Dm1), and the thickness of the probe is 6mm, therefore, 2.8\*6=16.8(%) were added to the normal intensity.
Also known as: Transcranial magnetic stimulation (TMS)
Oxygenated hemoglobin (HbO) change compared to baseline
iTBS-induced HbO change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 3 months
Deoxygenated hemoglobin (HbR) Change compared to baseline
iTBS-induced HbR change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 3 months
Oxygen saturation change compared to baseline
iTBS-induced oxygen saturation change in the DLPFC before, during and after stimulation
Time frame: During and post TBS-fNIRS measurement, up to 3 months
Plan to share: No
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This study is completed, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.
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The Hong Kong Polytechnic University