An observational study in Intraoperative Care and Fluid Responsiveness, sponsored by Istanbul Saglik Bilimleri University. Completed at 2 sites in Turkey. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2022-10-06.
Sponsored by Istanbul Saglik Bilimleri University · Observational
Optimizing fluid therapy is one of the main concerns for anesthesiologists during the intraoperative period. It becomes even more important in high-risk long lasting surgeries as pancreaticoduodenectomy. Therefore evaluating fluid responsiveness prior to fluid loading is highly recommended. To the best of our knowledge there is no study comparing the abilities short time low PEEP challenge and mini fluid challenge in predicting fluid responsiveness.
Istanbul Saglik Bilimleri University is the lead sponsor of 58 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients undergoing pancreaticoduodenectomy
Exclusion Criteria:
Other: Fluid Loading
Hemodynamic and ventilatory parameters will be recorded at five time points (T1 - T5). After baseline meausrements (T1), additional 5 cmH2O PEEP will be applied to patients for 30 seconds (short time low peep challenge, SLPC). Prior to PEEP lowering T2 measurement will be performed. T3 measurement will be performed one minute after PEEP is decreased to its initial value and will be recorded as the second baseline. Thereafter, 100 ml isotonic saline will be infused over one minute (MFC). T4 measurement will be performed one minute after MFC is completed,. Lastly, T5 measurement will be performed three minutes after additional 400 ml of isotonic saline is infused within 10 minutes to complete 500 ml of fluid loading.
Difference between the abilities of two methods to predict fluid responsiveness defined as an increase in stroke volume index >15% after fluid loading
Difference between the area under reciever operating characterisitcs curve of two methods
Time frame: one day
Plan to share: Undecided
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This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Istanbul Saglik Bilimleri University