An interventional study of Acute psychological stress in Acute Psychological Stress, sponsored by Baylor University. Completed at 1 site in United States. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-24.
Sponsored by Baylor University · Not applicable, Interventional, and Basic science
The present study will examine cardiovascular, metabolic, and neural responses to acute psychological stress using a cross-sectional approach.
All participants in this study will undergo an acute psychological stress paradigm, consisting of two acute psychological stress tasks (MSIT and Stoop). There is no formal randomization since al participants are randomized to undergo the acute psychological stress tasks.
Baylor University is the lead sponsor of 40 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Multi-source interference task (MSIT; Stroop)
Other: Acute psychological stress
Experimental: Acute psychological stress Two, acute-psychological stress tasks known to reliably elicit a cardiovascular responses (Multi-source interference task; Stroop).
Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline)
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
Time frame: 18 minutes (approximately 9 minutes for each task)
Heart Rate (Bpm) Measured by Electrocardiogram
Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline).
Time frame: 18 minutes (approximately 9 minutes for each stress task)
Neural Activity Measured by fMRI
Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels.
Time frame: 18 minutes (approximately 9 minutes for each stress task).
Recruited in Waco, Texas area
| Milestone | Acute Psychological Stress |
|---|---|
| Started | 170 |
| Completed | 170 |
| Not completed | 0 |
Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
| mL/(kg·min) | Acute Psychological Stress Task |
|---|---|
| Stroop task | 0.265 ± 0.452 |
| MSIT task | 0.287 ± 0.431 |
Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline).
| beats per minute (bpm) | Acute Psychological Stress |
|---|---|
| Stroop task | 4.926 ± 7.456 |
| MSIT | 2.826 ± 6.317 |
Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels.
| BOLD signal (Incon - Con) | Acute Psychological Stress |
|---|---|
| L Parietal_inf (stroop) | 0.71 ± 0.41 |
| R Angular (stroop) | 0.54 ± 0.35 |
| R Supp_Motor_Area (stroop) | 1 ± 0.65 |
| L Frontal_Inf_Tri (stroop) | 0.85 ± 0.56 |
| L Parietal_Inf2 (stroop) | 0.66 ± 0.45 |
| R Insula (stroop) | 0.70 ± 0.50 |
| R Frontal_Inf_Oper (stroop) | 0.76 ± 0.60 |
| R Vermis (stroop) | 0.84 ± 0.68 |
| R Thalamus (stroop) | 0.48 ± 0.40 |
| L Precuneus2 (stroop) | -0.55 ± 0.52 |
| L ParaHippocampal2a (stroop) | -0.47 ± 0.50 |
| L Angular2 (stroop) | -0.49 ± 0.54 |
| L Frontal_Med_Orb2 (stroop) | -1.38 ± 1.57 |
| L Frontal_Sup2 (stroop) | -0.55 ± 0.66 |
| L ParaHippocampal2 (stroop) | -0.47 ± 0.58 |
| R ParaHippocampal2 (stroop) | -0.35 ± 0.46 |
| R Precentral2 (stroop) | -0.20 ± 0.31 |
| R Rolandic_Oper2 (stroop) | -0.19 ± 0.33 |
| R Angular2 (stroop) | -0.23 ± 0.45 |
| R Amygdala2 (stroop) | -0.21 ± 0.43 |
| R Frontial_Sup2 (stroop) | -0.24 ± 0.54 |
| R Cerebelum_Crus2 (stroop) | -0.29 ± 0.91 |
| L Parietal_Inf (MSIT) | 0.50 ± 0.40 |
| R Parietal_Inf (MSIT) | 0.49 ± 0.43 |
| R Angular (MSIT) | 0.35 ± 0.31 |
| L Supp_Motor_Area (MSIT) | 0.49 ± 0.45 |
| L Frontal_Inf_Oper (MSIT) | 0.54 ± 0.52 |
| R Calcarine (MSIT) | 0.45 ± 0.48 |
| R Frontal_Inf_Oper (MSIT) | 0.49 ± 0.53 |
| R Insula (MSIT) | 0.49 ± 0.54 |
| R Frontal_Mid (MSIT) | 0.31 ± 0.37 |
| L Thalamus (MSIT) | 0.32 ± 0.39 |
| L Frontal_Mid_Orb (MSIT) | 0.25 ± 0.53 |
| L Cingulum_Mid2 (MSIT) | -0.40 ± 0.41 |
| L Angular2 (MSIT) | -0.51 ± 0.62 |
| L Frontal_Sup2 (MSIT) | -0.43 ± 0.52 |
| L Frontal_Med_Orb2 (MSIT) | -1.06 ± 1.33 |
| R Hippocampus2 (MSIT) | -0.24 ± 0.37 |
| R Angular2 (MSIT) | -0.27 ± 0.46 |
| R Insula2 (MSIT) | -0.21 ± 0.35 |
| R Temporal_Mid2 (MSIT) | -0.32 ± 0.63 |
| R Cerebellum_Crus2 (MSIT) | -0.42 ± 0.83 |
| R Precentral2 (MSIT) | -0.10 ± 0.30 |
| L Cerebellum_Crus2 (MSIT) | -0.26 ± 0.88 |
Collected over 4 total hours (participants were monitored during each of the 2 hour lab visits).. Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Acute Psychological Stress | 0/170 (0%) | 0/170 (0%) | 0/170 (0%) |
| Age, Categorical(Participants) | Acute Psychological Stress |
|---|---|
| <=18 years | 0 |
| Between 18 and 65 years | 170 |
| >=65 years | 0 |
| Age, Continuous(years) | Acute Psychological Stress |
|---|---|
| Mean | 22.08 ± 2.93 |
| Sex: Female, Male(Participants) | Acute Psychological Stress |
|---|---|
| Female | 87 |
| Male | 83 |
| Ethnicity (NIH/OMB)(Participants) | Acute Psychological Stress |
|---|---|
| Hispanic or Latino | 38 |
| Not Hispanic or Latino | 132 |
| Unknown or Not Reported | 0 |
| Race (NIH/OMB)(Participants) | Acute Psychological Stress |
|---|---|
| American Indian or Alaska Native | 3 |
| Asian | 30 |
| Native Hawaiian or Other Pacific Islander | 0 |
| Black or African American | 21 |
| White | 103 |
| More than one race | 13 |
| Unknown or Not Reported | 0 |
| Region of Enrollment(Participants) | Acute Psychological Stress |
|---|---|
| United States | 170 |
Documents are hosted by the registry — open the source record to download them.
Plan to share: No — There is no plan to share IPD with other rsearchers.
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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