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Status unknownNCT05374148Updated May 16, 2022

Respiratory Health Problems Among Workers in Ferrosilicon Alloys Industry in Aswan-Eygpt.

An observational study in Respiratory Disease, sponsored by Assiut University. Status unknown. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2022-05-16.

Sponsored by Assiut University · Observational

The sponsor has not verified this record recently (last verified May 2022), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
250
Ages
18 Years to 60 Years
Sex
All
01

Study summary

To minimize the negative effects of exposure to silica, iron chips, and coke on the respiratory health of workers in the Ferro alloy factory, so it is important to assess and diagnose their health-related effects. Early reporting, diagnosis, and intervention can limit the severity of health hazards, improve health services. To our knowledge, no local previous studies were done in this area. All over the world there is no sufficient information relating to this industry and its health hazards.

Read the detailed description

Ferrosilicon alloy is a mixture of iron and silicon. It's added to steel and cast iron. By oxidation of the iron, it offers superior properties to iron such as high strength, hardness, and resistance to corrosion and high temperatures. Around 90% of ferrosilicon alloys is consumed in the production of iron and steel. Silica dust is a secondary product of ferrosilicon industry. Its addition to concrete improve its chemical and physical properties[1] .

Ferrosilicon is an alloy of iron and silicon with high silicon content. Ferrosilicon alloys are produced in electric arc furnaces. At very high temperatures (2000°C). These furnaces are charged with quartz which is the main source of silica, iron chips, and coke which is used as a reducing agent. The industry process produces very fine particles of amorphous silica (SiO 2) powder(fume). The composition of the fumes varies somewhat according to which alloy is produced. In the production of ferrosilicon alloy with a high silicon content, the amount of Si02 in the fumes can be 80% or more[2].

Workers in the ferroalloy industry have been exposed to a variety of gases, fumes, and dust that may adversely affect the respiratory system. Among employees in Ferrosilicon plants, there is an increase in mortality rate from bronchitis, emphysema, and asthma[3]. Occupational exposure to respirable crystalline silica (SiO2) is one of the most common and serious hazards. It is considered a serious hazard for the ferrosilicon industry. Silicosis is the disease most associated with crystalline silica exposure. It causes by the inhalation of respirable crystalline silica dust [4]. It is a fibrotic lung disease progressive, irreversible, [5]. It is incurable but preventable[6]. Chronic Silicosis occurs due to the prolonged inhalation of respirable crystalline silica dust [4]. The major risk factors for developing silicosis include cumulative lifetime exposure, the total amount of inhaled crystalline Silica, silica size(0.5-3 µ) and individual susceptibility [6]. Thus, making silica dust one of the greater public health problems.

Silicosis is considered one of the most serious occupational diseases in the world. According to many previous studies, a large number of workers are exposed to silica dust throughout the world. At least 3.2 million workers in Europe and more than 2 million in the United States are exposed to silica dust[4] . In Asia, the prevalence of silicosis is up to 55% among workers exposed to silica dust, while in Latin America, the prevalence is up to 37%[8] In Egypt ,the prevalence rate of silicosis ranges from 18.5 % to 45.8% among workers exposed to free crystalline silica dust[9] Although many studies illustrated the relationship between silica exposure and silicosis occurrence in a different industries , there are no sufficient studies relating to the ferrosilicon industry and its respiratory hazards.

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Conditions studied

03

In context

Respiratory Tract Diseases

617 studies on the registry are indexed under Respiratory Tract Diseases; 111 are open to participants now.

This study's planned enrollment of 250 is below the median of 294 across 216 observational studies indexed under Respiratory Tract Diseases.

Browse Respiratory Tract Diseases studies →

Lead sponsor

Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Sampling method
Probability sample

Study population

workers exposed to free silica who have a free pre-employment records

Inclusion criteria

  • Active working miners working in ferrosilicon alloy factory with minimum exposure 5 years.
  • Workers exposed to silica, iron chips, and coke in quarry and Furnaces areas.
  • Have free pre-employment records especially free chest x-rays. have no previous pre- employment history of any chest problems.

Exclusion criteria

Exclusion Criteria:

    • Workers don't record silica, iron chips, and coke exposer as in the administration department.

      • Workers with less than 5-year exposure.
      • Workers are known to have chest diseases before joining the work for example emphysema and COPD.
05

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
250 participants (estimated)
Patient registry
No

Interventions

  • Behavioralhealth education

    health education to prevent respiratory diseases among workers

06

What researchers measure

Primary outcomes

  1. prevalence

    prevalence of silicosis among ferrosilicon industry workers.

    Time frame: 1 year

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Kalliny MS, Bassyouni MI. Immune response due to silica exposure in Egyptian phosphate mines. J Health Care Poor Underserved. 2011;22(4 Suppl):91-109. doi: 10.1353/hpu.2011.0156. PubMed 22102308 ↗
  • Leung CC, Yu IT, Chen W. Silicosis. Lancet. 2012 May 26;379(9830):2008-18. doi: 10.1016/S0140-6736(12)60235-9. Epub 2012 Apr 24. PubMed 22534002 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 16, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05374148
Lead sponsor
Assiut University
Responsible party
Alaa Bazied Dardir mohamed (Assistant lecturer, Assiut University) — Principal investigator
First posted
May 16, 2022
Start date
Sep 1, 2022 (estimated)
Primary completion
Sep 1, 2023 (estimated)
Completion
Oct 1, 2023 (estimated)
Last update
May 16, 2022

Study contacts

Alaa Bazied, B.C.C.H
Contact
ala2238972@gmail.com
+201155836349
Mariam Elkhayat, PHD
Contact
Mariam.Elkhayat@yahoo.com
01003708261

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2022. You cannot join it, but the record below documents what was studied.

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