An interventional study of Propofol Injection in Propofol, Glioma and Auditory Event-related Potential (AERP), sponsored by Beijing Tiantan Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-01.
Sponsored by Beijing Tiantan Hospital · Not applicable, Interventional, and Other
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity. Most of the current anesthesia depth monitoring methods are based on healthy brain function population，which is difficult to reflect the sedation depth of glioma patients accurately. Therefore, this study aims to explore the characteristics of brain network connectivity in glioma patients under different sedation depths by electroencephalogram (EEG) and auditory event-related potential (AERP) methods, which may provide a research basis for sedative titration and anesthesia depth identification in glioma patients.
1,397 studies on the registry are indexed under Glioma; 351 are open to participants now.
This study's planned enrollment of 60 is above the median of 32 across 1,065 interventional studies indexed under Glioma.
Browse Glioma studies →Beijing Tiantan Hospital is the lead sponsor of 465 studies on the registry; 282 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Drug: Propofol Injection
Drug: Propofol Injection
1% propofol is used for target-controlled infusion, and gradually increase the effect concentration at 0.2ug/ml. Make the subject's sedation depth reach light sedation and deep sedation respectively. EEG data were collected during wakefulness, light sedation, deep sedation, and recovery.
The amplitude of auditory event-related potential
The amplitude of MMN and P300
Time frame: During the trial(up to 3 hours for each subject)
The latency of auditory event-related potential
The latency of MMN and P300
Time frame: During the trial(up to 3 hours for each subject)
Brain network functional connectivity
Using coherence ; phase slope index(PSI); phase locking value(PLV）;phase lag index(PLI）to evaluate the brain network functional connectivity of subjects
Time frame: During the trial(up to 3 hours for each subject)
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Beijing Tiantan Hospital