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Active, not recruitingNCT05331625Updated Jul 16, 2026

Understanding Quality of Life Among Patients With Cancer Receiving Palliative Care

An interventional study of Offering Additional Resources to Promote Symptom Management in Cancer, sponsored by Abramson Cancer Center at Penn Medicine. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-16.

Sponsored by Abramson Cancer Center at Penn Medicine · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
208
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This randomized controlled trial will assess the effects on quality of life of two approaches to symptom management among new patients referred to a palliative care oncology clinic.

02

Conditions studied

  • Cancer

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03

In context

Neoplasms

9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.

This study's planned enrollment of 208 is above the median of 50 across 7,253 interventional studies indexed under Neoplasms.

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Lead sponsor

Abramson Cancer Center at Penn Medicine is the lead sponsor of 446 studies on the registry; 86 are open to participants now.

Of its 32 completed or terminated interventional studies of FDA-regulated products, 14 (44%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Be a new patient at an outpatient palliative care clinic
  • Resident of Pennsylvania
  • Over 18 years of age

Exclusion criteria

Exclusion Criteria:

  • Prior use of certain symptom focused therapies
  • Currently pregnant
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
208 participants (estimated)

Study arms

  • Experimental
    Intervention

    Participants in this group will consent to participate in a study about quality of life for patients with cancer seeking outpatient palliative care. They will be seen in a palliative care oncology clinic at which time they will be offered additional resources to promote symptom management. They will be asked to complete a series of surveys every two weeks for 16 weeks which will assess their quality of life, symptoms, and medication use.

    Behavioral: Offering Additional Resources to Promote Symptom Management

  • No intervention
    Usual Care

    Participants in this group will consent to participate in a study about quality of life for patients with cancer seeking outpatient palliative care. They will be seen in a palliative care oncology clinic where they will receive symptom management and supportive care. They will be asked to complete a series of surveys every two weeks for 16 weeks which will assess their quality of life, symptoms, and medication use.

Interventions

  • BehavioralOffering Additional Resources to Promote Symptom Management

    Participants will be offered additional resources to promote symptom management.

06

What researchers measure

Primary outcomes

  1. Quality of Life - McGill Quality of Life Questionnaire

    Quality of life will be measured through the McGill Quality of Life Questionnaire Revised (MQOL-R). The questionnaire is 15 questions assessing overall and specific areas of quality of life.

    Time frame: Baseline - 16 weeks

Secondary outcomes

  1. Feasibility of Accessing Additional Resources for Symptom Management

    Feasibility will be measured by whether participants accessed the additional resources for symptom management.

    Time frame: Baseline - 16 weeks

  2. Acceptability of Accessing Additional Resources for Symptom Management

    Acceptability will be measured by whether participants accessed the additional resources for symptom management.

    Time frame: Baseline - 16 weeks

  3. Symptom Severity

    Symptom severity will be measured through the Edmonton Symptom Assessment System (ESAS). The survey is 10 questions assessing the severity of pain, nausea, depression, etc. on a 0 to 10 scale-in which a 0 representing best possible state/symptom absence and a 10 representing worst possible state.

    Time frame: Baseline - 16 weeks

  4. Medication Use

    Medication use will be measured through a medication diary created for the study. The medication diary asks participants about recent medications, amounts, and dosages.

    Time frame: Baseline - 16 weeks

  5. Hospital-Free Days

    Hospital-free days will be measured through examination of participant's electronic health record.

    Time frame: Baseline - 16 weeks

  6. Mortality

    Mortality will be measured through examination of participant's electronic health record.

    Time frame: Baseline - 16 weeks

07

Study locations

1 site
  • University of Pennsylvania
    Philadelphia, Pennsylvania 19104, United States
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 16, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05331625
Lead sponsor
Abramson Cancer Center at Penn Medicine
Responsible party
Scott Halpern (Associate Professor of Medicine, University of Pennsylvania) — Principal investigator
First posted
Apr 15, 2022
Start date
Nov 3, 2022
Primary completion
Dec 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Jul 16, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

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